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In vitro Antiplasmodial Activity and Cytotoxicity of Ten Plants Used as Traditional Medicine in Malaysia

Wan Omar Abdullah, and Baharudin Omar, and Mohamed Kamel Abd Ghani, and Ngah Zasmy Unyah, and Rukman Awang Hamat, and Rayani, Mohamad, and Hatam, Gholam Reza, (2011) In vitro Antiplasmodial Activity and Cytotoxicity of Ten Plants Used as Traditional Medicine in Malaysia. Jurnal Sains Kesihatan Malaysia, 9 (2). pp. 5-8. ISSN 1675-8161

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Official URL: http://www.fsk.ukm.my/journal/vol9(2).html

Affiliations

Universiti Putra Malaysia. Faculty of Medical and Health Sciences
Universiti Kebangsaan Malaysia. Faculty of Health Sciences
Universiti Kebangsaan Malaysia. Faculty of Health Sciences
Universiti Putra Malaysia. Faculty of Medical and Health Sciences
Universiti Putra Malaysia. Faculty of Medical and Health Sciences
Shiraz University of Medical Sciences, Iran
Shiraz University of Medical Sciences, Iran

Abstract

Dichloromethane and methanolic extracts of each plant were tested for their antiplasmodial activity on chloroquineresistant strain of Plasmodium falciparum (FCB strain), based on lactate dehydrogenase activity. Cytotoxicity was assessed with the MTT test on MRC-5 human diploid embryonic lung cells. Most extracts of ten selected plants used in Malay traditional medicine in Malaysia had activity in vitro. This supports continued investigations of traditional medicine in the search for new antimalarial agent. The compounds responsible for the observed antiplasmodial effects are under investigation.

Item Type:Journal
Keywords:Plasmodium falciparum, Plant, Antiplasmodial activity, Cytotoxicity, Malaysia, Tumbuhan, Aktiviti antiplasmodium, Sitotoksisiti
Subjects:R Medicine, Dentistry, Pharmacy, Nursing
ID Code:12296

Douki, J.B., Sterkers, Y., Lepolard, C., Traore, B., Costa, F.T.,Scherf, A. & Gysin, J., 2003. Adhesion of normaland

Plasmodium falciparum ring-infected erythrocytes to

endothelial cells and the placenta involves the rhoptryderived ring surface protein. Blood 101: 5025-5032.

Hakizamungu, E. & Weri, M. 1988. L’usage de plantes médicinales dans le traitement du paludisme en médicine traditionnelle Rwandaise. Bulletin de Médecine et Pharmacie 2: 11-17.

Jonville, M.C., Kodja, H., Humeau, L., Fournel, J., De Mol, P., Cao, M., Angenot, L. & Frederich, M. 2008. Screening of

medicinal plants from Reunion Island for anti-malarial and

cytotoxic activity. Journal of Ethnopharmacology 120:

382-386.

Kaddouri, H., Nakache, S., Houze,S., Mentre, F., LeBras, J.

2006. Assessment of the drug susceptibility of Plasmodium

falciparum clinical isolates from Africa by using a

Plasmodium lactate dehydrogenase immunodetection

assay and an inhibitory maximumeffect model for precise

measurementof the 50-percent inhibitory concentration.

Antimicrobial Agents and Chemotherapy 50: 3343-3349.

Kaur, K., Jain, M., Kaur, T. & Jain, R. 2009. Antimalarials

from nature. Bioorganic & Medicinal Chemistry 17: 3229-

3256.

Lee, S.J., Park, W.H. & Moon, H.I. 2009. Bioassay-guided

isolation of antiplasmodial anacardic acids derivatives from

the whole plants of Viola websteri Hemsl. Parasitology

Research 104: 463-466.

Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods 65: 55-63.

Rajakumar, N. & Shivanna, M.B. 2009. Ethno-medicinal

application of plants in the eastern region of Shimoga

District, Karnataka, India. Journal of Ethnopharmacology

126, 64-73.

Trager, W. & Jensen, J.B. 1976. Human malaria parasites in

continuous culture. Science 193: 673-675.

Wan Omar, A., Ngah Zasmy, U., Zarida, M. Z. & Nor Rain, A.

2007. In Vitro and in vivo antiplasmodial properties of some

Malaysian plants used in traditional medicine. Infectious

Disease Journal of Pakistan 15(4): 97-101.

World Health Organisation. 2008. Malaria Report 2008. WHO

Report.

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