Author, Subjects, Keywords

Cited Author

 
 
   » By Author or Editor
 » Browse Author by Alphabet
 » By Journal
 » By Subjects
 » By Affiliations
 » By Type
 » By Year
 » By Latest Additions
 
 
   » By Author
 » Top 20 Authors
 » Top 20 Article
 » Top 20 Journal Cited
 » Top 20 Cited
 » Top 20 Author Cited
 » Usage Since Sept 2007


 
 
 

Login | Create Account

Amlodipine-induced gingival overgrowth: a case report

Taib H., and Ali T.B.T., and Kamin S., (2007) Amlodipine-induced gingival overgrowth: a case report. Archives of Orofacial Sciences, 2 . pp. 61-64. ISSN 1823-8602

[img]
Preview
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
146Kb

Official URL: http://www.kck.usm.my/ppsg/official-journal.htm

Affiliations

Universiti Sains Malaysia. School of Dental Sciences
University of Malaya. Faculty of Dentistry
University of Malaya. Faculty of Dentistry

Abstract

Gingival overgrowth is frequently observed in patients taking certain drugs such as calcium channel blockers, anticonvulsants and immunosuppressant. This can have a significant effect on the quality of life as well as increasing the oral bacterial load by generating plaque retention sites. Amlodipine, a third generation calcium channel blockers has been shown to promote gingival overgrowth although in very limited cases reported. The management of gingival overgrowth seems to be directed at controlling gingival inflammation through a good oral hygiene regimen. However in severe cases, surgical excision is the most preferred method of treatment, followed by rigorous oral hygiene procedures. This case report describes the management of gingival overgrowth in a hypertensive patient taking amlodipine. Combination of surgical gingivectomy and CO2 laser treatment was used to remove the gingival overgrowth. CO2 laser surgery produced good hemostasis and less pain during the procedure and post operatively. This case report has also shown that periodontal treatment alone without a change in associated drug can yield satisfactory clinical response.

Item Type:Journal
Additional Information:The authors wish to thank Dr. Pauziah Ahmad for the photographs during prosthesis construction.
Keywords:Calcium channel blocker, CO2 laser, drug-induced, gingival overgrowth, gingivectomy
Subjects:R Medicine
ID Code:1624

American Academy of Periodontology (AAP) (2002). Lasers in Periodontics. J Periodontol, 73: 1231-1239.

Aoki A, Sasaki KM, Watanabe H and Ishikawa I (2004). Lasers in nonsurgical periodontal therapy. Perio 2000, 36: 59-97.

Barclay S, Thomason JM, Idle JR and Seymour RA. (1992). The incidence and severity of nifedipine-induced gingival overgrowth. J Clin Periodontol, 19: 311-314.

Drew HJ, Vogel RI, Molofsky W, Baker H and Frank O. (1987). Effect of folate on phenytoin hyperplasia. J Clin Periodontol, 14: 350-356.

Ellis JS, Seymour RA, Thomason JM, Monkman SC and Idle JR (1993). Gingival sequestration of amlodipine and amlodipine-induced gingival overgrowth. Lancet, 341: 1102-1103.

Hallmon WM and Rossmann JA (1999). The role of drugs in the pathogenesis of gingival overgrowth. A collective review of current concept. Perio 2000, 21: 176-196.

Ikawa K, Ikawa M, Shimauchi H, Iwakura M and Sakamoto S (2002). Treatment of gingival overgrowth induced by manidipine administration: a case report. J Periodontol, 72: 115-122.

Inoue F and Harrison J (1981). Folic acid and phenytoin hyperplasia. Lancet, 2: 86.

Jorgensen MG (1997). Prevalence of Amlodipine-Related Gingival Hyperplasia. J Periodontol, 68: 676-678.

Khera P, Zirwas MJ and English JC (2005). Diffuse gingival enlargement. J Am Acad Dermatol, 52: 491-499.

Lafzi A, Farahani RM and Shoja MA (2006). Amlodipine-induced gingival hyperplasia. Med Oral Patol Oral Cir Bucal, 11(6): E480-E482.

Lederman D, Lumerman H, Reuben S and Freedman PD (1984). Gingival hyperplasia associated with nifedipine therapy. Report of a case. Oral Surg Oral Med Oral Pathol, 57: 620-622.

Mavrogiannis M, Ellis JS, Thomason JM and Seymour RA (2006). The management of drug-induced gingival overgrowth. J Clin Periodontol, 33: 434–439.

Nery EB, Edson RG, Lee KK, Pruthi VK and Watson J (1995). Prevalence of nifedipine-induced gingival hyperplasia. J Periodontol, 66: 572-578.

Seymour RA (1991). Calcium channel blockers and gingival overgrowth. Br Dent J, 170: 376-379.

Seymour RA, Ellis JS, Thomason JM, Monkman S, and Idle JR (1994). Amlodipine-induced gingival overgrowth. J Clin Periodontol, 21: 281-283.

Seymour RA, Thomason JM and Ellis JS (1996). The pathogenesis of drug-induced gingival overgrowth. J Clin Periodontol, 23: 165-175.

Seymour RA, Ellis JS and Thomason JM (2000). Risk factors for drug-induced gingival overgrowth. J Clin Periodontol, 27(4): 217-223.

Seymour RA (2006). Effects of medications on the periodontal tissues in health and disease. Perio 2000, 4: 120-129.

Repository Staff Only: item control page
 
 
 
 
 
   
© Copyright 2007 MyAIS Faculty of Computer Science and Information Technology, University of Malaya – All Rights Reserved. Malaysian Abstracting and Indexing System is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.