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Prevention of Ethanol-induced Gastric Mucosal Injury by Ocimum basilicum Seed Extract in Rats

Mahmood A.A., and Sidik K. , and Fouad H.M., (2007) Prevention of Ethanol-induced Gastric Mucosal Injury by Ocimum basilicum Seed Extract in Rats. ASM Science Journal, 1 (1). pp. 1-6. ISSN 1823-6782

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Official URL: http://www.akademisains.gov.my

Affiliations

University of Malaya. Faculty of Medicine. Dept. of Molecular Medicine
University of Malaya. Faculty of Dentistry. Dept. of Oral Pathology, Oral Medicine and Priodontology

Abstract

Ocimum basilicum seed extracts were found to possess significant anti-ulcer activity against ethanol-induced ulceration in experimental animal models. Three groups of adult male rats were used, with each group consisting of six rats. Oral administration of absolute ethanol to rats pre-treated with 10% Tween 20® (Group 1) produced extensive haemorrhagic lesions of the gastric mucosa. Rats orally pre-treated with O. basilicum extract suspended in 10% Tween 20® (Group 2) or cimetidine in 10% Tween 20® (Group 3),
30 min before oral administration of absolute alcohol had significantly reduced (p<0.05) the formation of such lesions compared to Group 1 rats. Histologically, rats pre-treated with O. basilicum extract (Group 2) or cimetidine (Group 3) showed significantly (p<0.05) a marked inhibition or reduction of gastric damage, submucosal oedema and leucocytes infiltration compared to animals pre-treated with 10% Tween 20® (Group 1).

Item Type:Journal
Keywords:O. basilicum; seed extract; cimetidine; gastric ulcer; histology; ethanol-induce; rats
Subjects:R Medicine
ID Code:1780

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