Author, Subjects, Keywords

Cited Author

 
 
   » By Author or Editor
 » Browse Author by Alphabet
 » By Journal
 » By Subjects
 » By Affiliations
 » By Type
 » By Year
 » By Latest Additions
 
 
   » By Author
 » Top 20 Authors
 » Top 20 Article
 » Top 20 Journal Cited
 » Top 20 Cited
 » Top 20 Author Cited
 » Usage Since Sept 2007


 
 
 

Login | Create Account

Faecal prevalence of extended-spectrum ß-lactamase (ESBL)-producing coliforms in a geriatric population and among haematology patients

Nurul Atifah M.A., and Loo, H.K.C., and Wong, E.H., and Subramaniam, G., and Ho, S.E., and Selvi, P., and Parasakthi, N., and Kamarulzaman A., (2005) Faecal prevalence of extended-spectrum ß-lactamase (ESBL)-producing coliforms in a geriatric population and among haematology patients. Malaysian Journal of Pathology, 27 (2). pp. 75-81. ISSN 0126-8635

[img]
Preview
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
540Kb

Official URL: http://www.mjpath.org.my/past_issue/MJP2005.2/01Faecal.pdf

Affiliations

University of Malaya, Faculty of Medicine, Dept. of Medical Microbiology
University of Malaya, Faculty of Medicine, Dept. of Medical Microbiology
University of Malaya, Faculty of Medicine, Dept. of Medical Microbiology
University of Malaya, Faculty of Medicine, Dept. of Medical Microbiology
University of Malaya, Faculty of Medicine, Dept. of Medical Microbiology
University of Malaya, Faculty of Medicine, Dept. of Medical Microbiology
University of Malaya, Faculty of Medicine, Dept. of Medical Microbiology

Abstract

Antimicrobial resistance to the extended-spectrum cephalosporins is increasingly reported worldwide. In the local setting, nosocomial infections with multi-resistant Gram-negative bacilli are not uncommon and are a growing concern. However, there is limited data on the carriage rates of such organisms in the local setting. In May 2001, a prospective study was carried out to determine the enteric carriage rates of ceftazidime-resistant Gram negative bacilli (CAZ-R GNB) among residents of nursing homes and from in-patients of the geriatric and adult haematology wards of University Malaya Medical Centre. Ceftazidime-resistant Gram-negative bacilli (CAZ-R GNB) were detected in 25 samples (30%), out of which 6 were from nursing home residents, 5 from geriatric in-patients and 14 from the haematology unit. A total of 28 CAZ-R GNB were isolated and Escherichia coli (10) and Klebsiella pneumoniae (7) were the predominant organisms. Resistance to ceftazidime in E. coli and Klebsiella was mediated by extended-spectrum beta-lactamases (ESBLs). Although the majority of the CAZ-R GNB were from patients in the haematology ward, the six nursing home residents with CAZ-R GNB were enteric carriers of ESBL-producing coliforms. Prior exposure to antibiotics was associated with carriage of ESBL organisms and to a lesser extent, the presence of urinary catheters.

Item Type:Journal
Additional Information:This work was funded by the Government of Malaysia Research Grant IRPA 06-02-03-0759.
Keywords:ESBL, geriatric population, Gram negative bacilli
Subjects:R Medicine, Dentistry, Pharmacy, Nursing
ID Code:1806

Wiener J, Quinn JP, Bradford PA, Goering RV, Nathan C, Bush K, et al. Multiple antibiotic-resistant Klebsiella and Escherichia coli in nursing homes. JAMA SEA 1999; July/Aug : 13-8.

Livermore DM. Extended-spectrum β-lactamases in Resistance: Evolution and Epidemiology. In: Proceedings of the Symposium of Antibiotic Resistance: the challenge of the New Millenium. Birmingham: UK; 1999.

3. Cohen M. Epidemiology of drug resistance: implications for a post-antimicrobial era. Science 1992; 257:1050-5.

4. Meyer KS, Urban C, Eagen J, Berger BJ, Rahal JJ. Nosocomial outbreak of Klebsiella infection resistant to late-generation cephalosporins. Ann Intern Med 1993; 119:353-8.

5. Yang Y, Bhachech N, Bradford PA, Jett BD, Sahm DF, Bush K. Ceftazidime-resistant Klebsiella pneumoniae and Escherichia coli isolates producing TEM-10 and TEM-43 b-lactamases from St. Louis, Missouri. Antimicrob Agents Chemother 1998; 42: 1671-6.

6. Bradford PA, Cherubin CE, Idemyor V, Rasmussen BA, Bush K. Multiply resistant Klebsiella pneumoniae from 2 Chicago hospitals. Antimicrob Agents Chemother 1994; 38: 761-6.

7. Bradford PA, Urban C, Jaiswal A, Mariano N, Rasmussen,BA, Projan SJ, et al. ������������SHV-7, a novel Cefotaxime-hydrolyzing Beta-lactamase, identified in Escherichia isolates from hospitalised nursing home patients. Antimicrob Agents Chemother 1995; 39: 899-905.

8. Gouby A, Neuwirth C, Bourg G, Bouziges N, Carles-Nurit MJ, Despaux E, et al. ��������������������Epidemiological study by Pulsed-Field Gel Electrophoresis of an outbreak of extended-spectrum Beta-lactamase-producing Klebsiella pneumoniae in a geriatric hospital. J Clin Microbiol 1994; 32: 301-5.

9. Jacobson KL, Cohen SH, Inciardi JF, King JH, Lippert WE, Iglesias T, et al��. The relationship between antecedent antibiotic use and resistance to extended-spectrum cephalosporins in Group 1 Beta-lactamase-producing organisms. CID 1995; 21: 1107-13.

10. Cowan ST. Manual for the identification of Medical Bacteria. 2nd ed. Cambridge University Press; 1974; Appendix C: p166-80.

11. Jarlier V, Nicolas MH, Fournier G, Philippon A. Extended broad-spectrum beta-lactamases conferring transferable resistance to newer beta-lactams in Enterobacteriaceae: hospital prevalence and susceptibility patterns. Rev Infect Dis 1998; 10: 867-78.

12. National Committee for Clinical Laboratory Standards. Performance Standards for Antimicrobial Disk Susceptibility Tests. Approved Standard M2-A6. NCCLS Document. Wayne, Pa., 2003.

13. Neuwirth C, Siebor E, Lopez J, Pechinot A, Kazmierczak A. Outbreak of a TEM-24 producing Enterobacter aerogenes in an intensive care unit and dissemination of the extended-spectrum beta-lactamase to other members of the family Enterobacteriaceae. J Clin Microbiol 1996; 34: 76-9.

14. M’Zali FH, Heritage J, Gascoyne-Binzi DM, Denton M, Todd NJ, Hawkey PM. Transcontinental importation into the UK of Escherichia coli

81

FAECAL ESBL-PRODUCING COLIFORMS

expressing a plasmid-mediated AmpC-type β-lactamase exposed during an outbreak of SHV-5 extended-spectrum β-lactamase in a Leeds hospital. J Antimicrobial Chemother 1997; 40: 823-31

15. Billot-Klein D, Gutnmann L, Collatz E. Nucleotide sequence of the SHV-5 β-lactamase gene of Klebsiella pneumoniae plasmid. Antimicrobial Agents Chemother 1990; 34: 2439-41.

16. Philippon A, Labia R, Jacoby G. Extended-spectrum β-lactamases. Antimicrobial Agents Chemother 1989; 33: 1131-6.

17. Livermore DL, Yuan M. Antibiotic resistance and production of extended-spectrum beta-lactamases amongst Klebsiella spp. from intensive care units in Europe. J Antimicrobial Chemother 1996; 38: 409-24.

18. Thompson KS. Controversies about extended-spectrum and AmpC β-lactamases. Emerg Infect Dis 2001; 7: 333-5.

19. Palasubramaniam S, Subramaniam G, Sekaran M, Parasakthi N. SHV-5 extended-spectrum beta-lactamase from Klebsiella pneumoniae associated with a nosocomial outbreak in a paediatric oncology unit in Malaysia. Int J Infect Dis 2005; 9: 170-2.

Repository Staff Only: item control page
 
 
 
 
 
   
© Copyright 2007 MyAIS Faculty of Computer Science and Information Technology, University of Malaya – All Rights Reserved. Malaysian Abstracting and Indexing System is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.