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Histopathological landmarks of hepatocellular carcinoma in Malaysians

Cheah, PL, and Looi, LM, and Nazarina AR, and Goh, KL, and Rosmawati M , and Vijeyasingam R, (2003) Histopathological landmarks of hepatocellular carcinoma in Malaysians. Malaysian Journal of Pathology, 25 (1). pp. 37-43. ISSN 0126-8635

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Official URL: http://www.mjpath.org.my/past_issue/MJP2003.1/Hepatocellular%2004.pdf

Affiliations

University of Malaya Medical Centre, Dept. of Pathology
University of Malaya Medical Centre, Dept. of Pathology
University of Malaya Medical Centre, Dept. of Pathology
University of Malaya Medical Centre, Dept. of Internal Medicine
University of Malaya Medical Centre, Dept. of Internal Medicine
University of Malaya Medical Centre, Dept. of Surgery

Abstract

A study was conducted at the Department of Pathology, University of Malaya Medical Centre, Kuala Lumpur into the histological type (WHO classification), grade (modified Edmondson and Steiner’s grading system), mitotic rate, bile production, hyaline globule and Mallory hyaline formation of 52 cases of hepatocellular carcinoma (HCC) diagnosed during a 13-year period between 1st January 1990 to 31st December 2002. In addition, associated cirrhosis, dysplasia (large liver cell dysplasia: LLCD and small liver cell dysplasia: SLCD) and microvascular permeation were also looked for whenever the situation permitted. The patients’ ages ranged from 21-years to 85-years (mean = 58.7 years) with a predilection for males and Chinese. Histologically, majority (73.1%) of the tumours demonstrated a trabecular pattern of growth. The bulk (73%) of the tumours were either of grade II or III differentiation. Mitotic activity ranged between 0-100/10 high power fields (hpf) with a mean of 22.2/10 hpf. Bile was noted in 25%, hyaline globules 17.3% and Mallory bodies in one case. Concomitant cirrhosis was present in 73.5%. 73.5% of the cases had associated LLCD. 5 with LLCD also showed SLCD. Microvascular permeation was shown in 76.2% of cases. On comparison with findings from other studies, no major difference seems to exist between the histological characteristics of our HCC cases and that of other populations.

Item Type:Journal
Additional Information:This study was supported by the Malaysian Ministry of Science, Technology and Environment IRPA research grants: 36-02-03- 6018 and 36-02-03-6019
Keywords:Hepatocellular carcinoma, Malaysians, histological parameters
Subjects:R Medicine, Dentistry, Pharmacy, Nursing
ID Code:1811

1. Yu MC, Yuan JM, Govindarajan S, Ross RK. Epidemiology of hepatocellular carcinoma. Can J Gastroenterol 2000; 14:703-9

2. Department of Statistics, Malaysia. Vital statistics; 1996

3. Ishak KG, Anthony PP, Sobin LH. Histological typing of tumours of the liver. World Health Organization International Histological Typing of Tumours, 2nd ed. Berlin: Springer-Verlag, 1994

4. Edmondson HA, Steiner PE. Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer 1954; 7:462-503

5. Nzeako UC, Goodman ZD, Ishak KG. Comparison of tumor pathology with duration of survival of North American patients with hepatocellular carcinoma. Cancer 1995; 76:579-88

6. Anthony PP, Vogel CL, Barker LF. Liver cell dysplasia: a premalignant condition. J Clin Pathol 1973; 26:217-23

7. Watanabe S, Okita K, Harada T, Kodama T, Numa Y, Takemoto T, Takahashi T. Morphologic studies of the liver cell dysplasia. Cancer 1983; 51:2197-205

8. Chia KS, Lee HP, Lee J. Incidence of primary liver cancer in Singapore, 1968-1982. Ann Acad Med Singapore 1989; 18:313-6

9. Lim TC, Teh LB, Kwok KC, Ng HS, Ong YY, Seah CS. Hepatocellular carcinoma – a clinical study. Ann Acad Med Singapore 1986; 15:158-61

10. Wang TL, Yap IL, Tan YO. Hepatocellular carcinoma – a case series of 104 patients. Ann Acad Med Singapore 1991; 20:215-8

11. Sim HG, Ooi LL. Results of resections for hepatocellular carcinoma in a new hepatobiliary unit. ANZ J Surg 2003; 73:8-13

12. Bosch FX, Ribes J, Borras J. Epidemiology of primary liver cancer. Semin Liver Dis 1999; 19:271- 85

13. Linsell A. Primary liver cancer: epidemiology and etiology. In Wanebo HJ, ed. Hepatic and biliary cancer. New York: Dekker, 1986:pp 3-15

14. Bosch FX. Global epidemiology of hepatocellular carcinoma. In: Okuda K, Tabor E, eds. Liver cancer. New York: Churchill Livingstone, 1997:pp13-28

5. Sumithran E, Looi LM. Race-related morphologic variations in hepatocellular carcinoma. Cancer 1985; 56:1124-7

16. Joishy SK, Bennett JM, Balasegaram M, MacIntyre JM, Falkson G, Moertel C, Carbone PP. Clinical and chemotherapeutic study of hepatocellular carcinoma in Malaysia: a comparison with African and American patients. Cancer 1982; 50:1065-6

17. Okuda K, and the Liver Cancer Study Group of Japan. Primary liver cancers in Japan. Cancer 1980; 45:2663-9

18. Bhargava DK, Verma K, Dasarathy S. Laparoscopic and histological features of hepatocellular carcinoma. Indian J Med Res 1991;94:424-5

19. Kashala LO, Conne B, Kalengayi MMR, Kapanci Y, Frei PC, Lambert PH. Histopathologic features of epatocellular carcinoma in Zaire. Cancer 1990; 65:130-4

20. Rua S, Comino A, Fruttero A, Torchio P, Bouzri H, Taraglio S, Torchio B, Capussotti L. Flow cytometric DNA analysis of cirrhotic liver cells in patients with hepatocellular carcinoma can providea new prognostic factor. Cancer 1996; 78:1195- 202

21. Chapel F, Guettier C, Chastang C, Rached AA, Mathieu D, Tepper M, Beaugrand M, Trinchet JC. Needle biopsy of hepatocellular carcinoma: assessment of prognostic contribution of histologic parameters including proliferating cell nuclear antigen labeling and correlations with clinical outcome. Group d’Etude et de Traitement du Carcinoma Hepatocellulaire. Cancer 1996; 88:864-71

22. Ouchi K, Sugawara T, Fujiya T, Kamiyama Y, Kakugawa Y, Mikuni J, Yamanami H, Nakagawa K. Prediction of recurrence and extratumour spread of hepatocellular carcinoma following resection. J Surg Oncol 2000; 75:241-5

23. Ebelt J, Neid M, Tannapel A, Witzigmann H, Hauss J, Kockerling F, Wittekind C. Prognostic significance of proliferation markers in hepatocellular carcinoma (HCC). Zentralbl Chir 2000; 125:597-601

24. Ouchi K, Sugawara T, Ono H, Fujiya T, Kamiyama Y, Kakugawa Y, Mikuni J, Yamanami H, Komatsu S, Horikoshi A. Mitotic index is the best predictive factor for survival of patients with resected hepatocellular carcinoma. Dig Surg 2000; 17:42-8

25. Tannapfel A, Geissler F, Kockerling F, Katalinic A, Hauss J, Wittekind C. Apoptosis and proliferation in relation to histopathological variables and prognosis in hepatocellular carcinoma. J Pathol 1999; 187:439-45

26. Cohen C. Intracytoplasmic hyaline globules in hepatocellular carcinomas. Cancer 1976; 37:1754-8

27. Anthony PP. Tumours and tumour-like lesions of the liver and biliary tract: aetiology, epidemiology and pathology. IN: MacSween RNM, Burt AD,Portmann BC, Ishak KG, Scheuer PJ, Anthony PP, editors. Pathology of the liver, 4th ed. London: Churchill Livingstone; 2002. p 711-75

28. Irie H, Mori J, Dalmacio-Cruz AE, Guirnella EA, Zamuco JT. Hepatocellular carcinoma in the Philippines: a clinicopathologic study of 150 cases. Jpn J Cancer Res 1985; 76:297-300

29. Nayar R, Bourtsos E, DeFrias DV. Hyaline globules in renal cell carcinoma and hepatocellular carcinoma. A clue or a diagnostic pitfall on fineneedle aspiration. Am J Clin Pathol 2000; 114:576-82

30. Yeh CN, Chen MF, Lee WC, Jeng LB. Prognostic factors of hepatic resection for hepatocellular carcinoma with cirrhosis: univariate and multivariate analysis. J Surg Oncol 2002; 81:195-202

31. Belghiti J, Regimbeau JM, Durand F, Kianmanesh AR, Dondero F, Terris B, Sauvanet A, Farges O, Degos F. Resection of hepatocellular carcinoma: a European experience of 328 cases. Hepatogastroenterologoy 2002; 49:41-6

32. Herold C, Reck T, Fischler P, Ott R, Radespiel- Troeger M, Ganslmayer M, Hohenberger W, Hahn EG, Schuppan D. Prognosis of a large cohort of patients with hepatocellular carcinoma in a single European centre. Liver 2002; 22:23-8

33. Kojiro M. Premalignant lesions of hepatocellular carcinoma: pathologic viewpoint. J Hepatobiliary Pancreat Surg 2000; 7:535-41

34. Le Bail B, Bernard PH, Carles J, Balabaud C, Bioulae-Sage P. Prevalence of liver cell dysplasia and association with HCC in a series of 100 cirrhotic liver explants. J Hepatol 1997; 27:835-42

35. Szczepanski W. Liver cell dysplasia in liver cirrhosis and hepatocellular carcinoma. Pol J Pathol 1997; 48:147-57

36. Lee RG, Tsamandas AC, Demetris AJ. Large cell change (liver cell dysplasia) and hepatocellular carcinoma in cirrhosis: matched case-control study, pathological analysis, and pathogenetic hypothesis.Hepatology 1997; 26:1415-22

37. Esnaola NF, Lauwers GY, Mirza NQ, Nagorney DM, Doherty D, Ikai I, Yamaoka Y, Regimbeau JM, Belghiti J, Curley SA, Ellis LM, Vauthey JN. Predictors of microvascular invasion in patients with hepatocellular carcinoma who are candidates for orthotopic liver transplantation. J Gastrointest Surg 2002; 6:224-32

38. Lauwers GY, Terris B, Balis UJ, Batts KP, Regimbeau JM, Chang Y, Graeme-Cook F, Yamabe H, Ikai I, Cleary KR, Fujita S, Flejou JF, Zukerberg LR, Nagorney DM, Belghiti J, Yamaoka Y, Vauthey JN; The International Cooperative Study Group on Hepatocellular Carcinoma. Am J Surg Pathol 2002;26:25-34

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