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Epstein-Barr virus (EBV) and gastric carcinoma in Malaysian patients

Norain Karim, and Pallesen, Gorm, (2003) Epstein-Barr virus (EBV) and gastric carcinoma in Malaysian patients. Malaysian Journal of Pathology, 25 (1). pp. 45-47. ISSN 0126-8635

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Official URL: http://www.mjpath.org.my/past_issue/MJP2003.1/EBV%2005.pdf

Affiliations

Ipoh Hospital Perak. Dept. of Pathology
Rogaland Sentralsjukehus, Stavanger, Norway

Abstract

Epstein-Barr virus (EBV) has consistently been detected in the tumour cells of nasopharyngeal carcinoma and lymphoepithelial-like carcinoma of the salivary glands, and have occasionally been found in similar tumours at other sites. Moreover, recent studies from various parts of the world including the Orient have shown about 10% of gastric carcinomas to be EBV-associated. We studied 50 gastric carcinomas from Malaysia to investigate its association with EBV in the Malaysian population. They comprised 37 intestinal and 13 diffuse type carcinomas from 32 male and 18 female patients, age range from 29 to 86 years with an ethnic distribution of Malay: Chinese: Indian with the ratio of 4: 27: 19. EBV gene and gene-expression were examined in sections of formalinfixed, paraffin-embedded tissue using commercially available probes for detecting EBV encoded RNAs (EBERs) by in situ hybridization and monoclonal antibodies to EBV latent membrane protein- 1 (LMP-1) by standard immunohistochemistry. Five of 50 gastric carcinomas showed EBER intranuclear positivity in all tumour cells but no cases expressed LMP-1. The EBV-associated cases were classified as intestinal type in 4 and diffuse type in one case and all were histologically unremarkable. EBV-positive tumours were found in 3 Chinese and 2 Indian patients with none in the small Malay group. Four EBV-positive tumours were in male patients, with age-range of 65 to 86 years. We conclude that our findings of about 10% of Malaysian gastric carcinomas being EBV associated is in line with the results from other parts of the world and from other ethnic groups.

Item Type:Journal
Additional Information:The authors thank the Surgical Department of Hospital Ipoh for sharing the cases and the Director-General of the Malaysian Ministry of Health, Tan Sri Datu’ Dr Hj Mohamad Taha Arif for his encouragement.
Keywords:Epstein-Barr virus, gastric carcinoma
Subjects:R Medicine, Dentistry, Pharmacy, Nursing
ID Code:1812

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