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Tocotrienols-rich diet decreases advanced glycosylation endproducts in non-diabetic rats and improves glycemic control in streptozotocin-induced diabetic rats

Wan Nazaimoon WM, and Khalid BAK, (2002) Tocotrienols-rich diet decreases advanced glycosylation endproducts in non-diabetic rats and improves glycemic control in streptozotocin-induced diabetic rats. Malaysian Journal of Pathology, 24 (2). pp. 77-82. ISSN 0126-8635

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Official URL: http://www.mjpath.org.my/past_issue/MJP2002.2/Tocotrienols-richdiet%20decreases.pdf

Affiliations

Institute for Medical Research, Kuala Lumpur. Diabetes and Metabolic Disorders Unit
Universiti Kebangsaan Malaysia. Faculty of Medicine

Abstract

This study determined the effects of palm vitamin E (TRF) diet on the levels of blood glucose, glycated hemoglobin (gHb), serum advanced glycosylation end-products (AGE) and malondialdehyde(MDA) of diabetic Sprague-Dawley rats. The rats received either control (normal rat chow), TRF diet (normal chow fortified with TRF at lgkg) or Vitamin C diet (vitamin E-deficient but contained vitamin C at 45 gkg). The animals were maintained on the respective diet for 4 weeks, made diabetic with streptozotocin (STZ), then followed-up for a further 8 weeks. At week-4, mean serum AGE levels of rats given TRF diet (0.7f0.3 unitslml) were significantly lower than those of control or Vitamin C diet rats (~£0.03)T. he levels increased after STZ and became comparable to the other groups. At weekl2, blood glucose (20.9f6.9mM) and gHb (10.0f 1.6%) of rats on TRF diet remained significantly low compared to that of control or Vitamin C diet rats (~£0.03)M. DA however, was not affected and remained comparable between groups throughout the study. This study showed that TRF may be a useful antioxidant; effectively prevented increase in AGE in normal rats, and caused decrease in blood glucose and gHb in diabetic rats. Further studies are needed to elucidate the mechanisms of action of TRF.

Item Type:Journal
Additional Information:This study was funded by research grants nos. 06-02-02-0040 and 06-02-02-0046, obtained from the Ministry of Science, Technology and the Environment, Malaysia. The authors also wish to thank the Director of the Institute for Medical Research for permission to publish this study.
Keywords:Tocotrienols, streptozotocin, advaced glycosylation end-products, glycated hemoglobin
Subjects:R Medicine, Dentistry, Pharmacy, Nursing
ID Code:1814

1. Aoki Y, Yanagisawa Y, Yazaki K, Oguchi H, Kiyosawa K, Furuta S. Protective effect of vitamin E supplementation on increased thermal stability of collagen in diabetic rats. Diabetologia 1992; 35:913-6.

2. Ono Y, Aoki S, Ohnishi K, Yasuda T, Kawano K, Tsukada Y. Increased serum levels of advanced glycation end-products and diabetic complications. Diab Res Clin Pract 1998; 41: 131-7.

3. Brownlee M, Vlassara H, Cerami A. Nonenzymatic glycosylation and the pathogenesis of diabetic complications. Ann Intern Med 1984; 101: 527-37.

4. Lyons TJ. Lipoprotein glycation and its metabolic consequences. Diabetes 1992; 41 ( supp12): 67-73.

5. Ceriello A, Giugliano D, Quatraro A, Donzella C, Dipalo G, Lefebvre PJ. Vitamin E reduction of protein glycosylation in diabetes: New prospect for prevention of diabetic complications? Diab Care 1991; 14: 68-72.

6. Frei B, Stocker R, Ames BN. Antioxidant defenses and lipid peroxdation in human blood plasma. Proc Natl Acad Sci USA 1988; 85: 9748-52.

7. Jain SK, Mckie R, Jaramillo JJ, Palmer M, Smith T, Meachum ZD, Little RL. The effect of modest vitamin E supplementation on lipid peroxidation products and other cardiovascular risk factors in diabetic patients. Lipids 1996; 31: ,587-S90.

8. Rifici VA, Khachadurian AK. Dietary supplementation with vitamins C and E inhibits in vitro oxidation of lipoproteins. J Am Coll Nutr 1993; 12: 631-7.

9. Vannucchi H, Araujo WF, Bernardes MM, Jordao Junior-Jr AA. Effect of different vitamin E levels on lipid peroxidation in steptozotocin-diabetic rats. Int J Vitam Nutr Res 1999; 69: 250-4.

10. Taddei S, Virdis A, Ghiadoni L, Magagna A, A. Salvetti A. Vitamin C improves endotheliumdependent vasodilation by restoring nitric oxide activity inessentialhypertension. Circulation 1998;97: 2222-9.

11. Timimi K, Ting HH, Haley EA, Roddy M, Creager MA. Vitamin C improves endotheliumdependent vasodilation in patients with insulindependent diabetes mellitus. J Am Coll Cardiol 1998; 31: 552-7.

12. Ting HH, Timimi FK, Boles KS, Creager SJ, Ganz P, Creager MA. Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1996; 97: 22-8.

13. Hashimoto T, Kato A, Tanabe K, Mamuro H, Yamaoka M, Berger KG, Gapor AB. Studies on tocopherols and tocotrienols in Malaysian palm oil. Proceedings of the International Symposium on the advanced industrial utilization of the tropical plants, Tsukuba, Japan, 1980.

14. Wan Nazaimoon WM, Sakinah 0 , Gapor A, Khalid BAK. Effects of palm olein tocopherol and tocotrienol on lipid peroxidation, lipid profiles and glycemic control in non-insulin diabetes mellitus patients. Nutri Res 1996; 16:1901-1 1.

15. Yagi Y. A simple fluorometric assay for lipoperoxide in blood plasma. Biochem Med 1976; 15: 212-6.

16. Wan Nazaimoon WM, Khalid BAK. An enzyme immunoassay for advanced glycosylation endproducts in serum. Malays J Path01 1998; 20: 83-9.

17. Mitshuhashi T, Vlassara H, Founds HW, Li YM. Standardising the immunological measurement of advanced glycation endproducts using normal human serum. J Immunol Method 1997; 207: 79-

18. Koya D, Haneda M, Kikkawa R, King GL. Dalpha tocopherol treatment prevents glomerular dysfunctions in diabetic rats through inhibition of protein kinase C-diacylglycerol pathway. Biofactors 1998; 7: 69-76.

19. Kunisaki M, Bursell SE, Umeda F, Nawata H, King GL. Prevention of diabetes-induced abnormal retina1 blood flow by treatment with d-alphatocopherol. Biofactors 1998; 7: 55-67.

20. Paolisso G, D'Amore A, D. Galzerano D, Balbi V, Giugliano D, Varricchio M, D'Onofrio F. Daily vitamin E supplements improve metabolic control but not secretion in elderly type I1 diabetic patients. Diab Care 1993; 16: 1433-7.

21. Jialal I, Fuller CJ, Huet BA. The effect of atocopherol supplementation on LDL oxidation: A dose-response study. Arterioscler Thromb Vasc Biol 1995; 15: 190-7.

22. Rimm EB, Stampfer MJ, Acherio E, Giovannici GA, Colditz WC, Willett WC. Vitamin E consumption and the risk of coronory heart disease in man. N Engl J Med 1993; 328: 1450-6.

23. Watson RR, Leonard TK. Selenium and vitamins A, E and C: nutrients with cancer prevention. JAMA 1986; 85: 505-10.

24. Slonim AE, Surber ML, Page DL, Sharp RA, Burr IM. Modification of chemically induced diabetes in rats by vitamin E. J Clin Invest 1983;71: 1282-8.

25. Lee S-H, Park I-S. Effects of soybean diet on the b cells in the streptozotocin treated rats for induction of diabetes. Diab Res Clin Prac 2000; 47: 1-13.

26. Giugliano D, Ceriello A, Paolisso G. Oxidative stress and diabetic vascular complications. Diab Care 1996; 3: 257-7.

27. Steinbrecher UP, Zhang H, Lougheed M. Role of oxidatively modified LDL in atherosclerosis. Free Radic Biol Med 1990; 9: 155-68.

28. Wautier JL, Guillausseau PJ. Diabetes, advanced glycation endproducts and vascular disease. Vascular Med 1998; 3: 131-7.

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