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The Oral Mucosa and Langerhans Cells in Smokers: Evidence for Carcinogenesis

Khoo, Suan Phaik, and Lee, K.W., (1995) The Oral Mucosa and Langerhans Cells in Smokers: Evidence for Carcinogenesis. Annals of Dentistry, 2 (1). pp. 1-4. ISSN 0128-7532

Full text not available from this repository.

Official URL: http://ejum.fsktm.um.edu.my/ArticleInformation.aspx?ArticleID=544

Affiliations

University of Malaya. Faculty of Dentistry. Dept. of Oral Pathology
University of Malaya. Faculty of Dentistry. Dept. of Oral Pathology

Abstract

A study was carried out to investigate whether smoking had any effecton the Langerhans cells in the oral mucosa, which might throw light onto the mechanism of malignant transformation of some keratotic lesions in the oral cavity. Thirty-two cases of keratotic lesions from biopsy specimens of smokers and non-smokers were studied. Langerhans cells were identified by immunocytochemical staining for 5100 proteins and their densities quantified. Smokers were associated with a significant reduction in the Langerhans cell population compared to non-smokers. The mean values of Langel:lans cell density in light smokers and heavy smokers were 28.64/mm2 and 33.421mm2 respectively compared to 66.51/mm2 in nonsmokers. There was a dose-response relation between the number of cigarettes smoked daily and the effect on cell counts. These findings of a local immunological effect of smoking on oral epithelium may explain the means by which cigarette smoking contributes to the development of oral cancer.

Item Type:Journal
Keywords:Smoking, Langerhans cells, oral epithelium, malignant transformation
Subjects:R Medicine, Dentistry, Pharmacy, Nursing
ID Code:2161

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