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Effects of Ginger Extract (Zingiber officinale Roscoe) on Antioxidant Status of Hepatocarcinoma Indu

Norliza Ahmad, and Suhaniza Sulaiman, and Nor Ashikeen Mukti, and Nor Azian Murad, and Noor Aini Abd Hamid, and Yasmin Anum Mohd Yusof, (2006) Effects of Ginger Extract (Zingiber officinale Roscoe) on Antioxidant Status of Hepatocarcinoma Indu. Malaysian Journal of Biochemistry and Molecular Biology, 14 (1). pp. 7-12. ISSN ISSN 1511-2616

Full text not available from this repository.

Official URL: http://ejum.fsktm.um.edu.my/ArticleInformation.aspx?ArticleID=581

Affiliations

Universiti Kebangsaan Malaysia. Faculty of Medicine. Dept. of Biochemistry
Universiti Kebangsaan Malaysia. Faculty of Medicine. Dept. of Biochemistry
Universiti Kebangsaan Malaysia. Faculty of Medicine. Dept. of Biochemistry
Universiti Teknologi Malaysia. Centre of Lipids, Engineering and Applied Research
Universiti Kebangsaan Malaysia. Faculty of Medicine. Dept. of Biochemistry
Universiti Kebangsaan Malaysia. Faculty of Medicine. Dept. of Biochemistry

Abstract

Ginger or Zingiber officinale which is used in traditional medicine has been found to possess antioxidant effect that can control the generation of free radicals. Free radical level has been reported to be high in cancer cells. The aim of this study was to observe the effect of ginger extract on antioxidant status in rats induced with liver cancer. Twenty-six male Wistar rats were divided into 5 groups: 2 control groups were fed with normal rat chow and olive oil respectively. Treatment groups consisted of rats fed with ginger extract at 100 mg/kg body weight (ginger group), rats induced with liver cancer by choline deficient diet plus ethionine in drinking water (CDE group) and rats with CDE diet plus ginger extract (CDE + ginger group) . Blood samples were taken from the orbital sinus at 0 and 8 weeks of experiment for the determination of antioxidant enzyme activities and MDA level. Comparison between the control group and the CDE group showed significant increase (p<0.05) in SOD activity at 8 week of experiment, whereas no significant differences were observed in the activities of GPx, catalase and the MDA level. Antioxidant effect of ginger extract was observed by the significant decrease (p<0.05) in SOD activity and the level of MDA in CDE group after treatment with ginger when compared to CDE group alone and with the control group. Catalase activity increased significantly (p<0.05) in CDE group after supplementation with ginger at week 8 of experiment when compared to CDE group alone, while there were no significant changes observed for GPx. From this study, it can be concluded that free radicals are increased in liver carcinogenesis (as evidenced by an increase in SOD activity) and ginger extract exhibits anticancer effect by scavenging the free radicals (decrease in SOD activity).

Item Type:Journal
Keywords:Zingiber officinale, antioxidant, hepatocarcinoma induced rats
Subjects:Q Science, Computer Science
R Medicine, Dentistry, Pharmacy, Nursing
ID Code:2189

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