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Effects of Palm Vitamin E Against Oxidative Damage in Streptozotocin-induced Diabetic Rats

Siti Balkis Budin, and Nor Fadilah Rajab, and Khairol Osman, and Abdul Gapor Mat Top , and Wan Nazaimoon Wan Mohamud, and Mokhtar Abu Bakar, and Jamaludin Mohamed, (2006) Effects of Palm Vitamin E Against Oxidative Damage in Streptozotocin-induced Diabetic Rats. Malaysian Journal of Biochemistry and Molecular Biology, 13 (1). pp. 11-17. ISSN ISSN 1511-2616

Full text not available from this repository.

Official URL: http://ejum.fsktm.um.edu.my/ArticleInformation.aspx?ArticleID=587

Affiliations

Universiti Kebangsaan Malaysia. Faculty of Allied Health Sciences. Dept. of Biomedical
Universiti Kebangsaan Malaysia. Faculty of Allied Health Sciences. Dept. of Biomedical
Universiti Kebangsaan Malaysia. Faculty of Allied Health Sciences. Dept. of Biomedical
Malaysian Palm Oil Board
Institute for Medical Research Malaysia.
Universiti Kebangsaan Malaysia. Faculty of Medicine. Dept. of Pathology
Universiti Kebangsaan Malaysia. Faculty of Allied Health Sciences. Dept. of Biomedical

Abstract

Palm vitamin E, which rich in tocotrienol is a highly effective antioxidant and able to reduce oxidative stress in various pathological conditions. Diabetes mellitus is often associated with increase in the production of reactive oxygen species together with reduction in antioxidants levels. In order to elucidate the antioxidative effects of palm vitamin E, we investigated the effects of 8 weeks supplementation with palm vitamin E on glycaemic status, malondialdehyde levels and DNA damage in Streptozotocininduced diabetic rats. Alkaline Comet Assay assessed protective effects against DNA damage to peripheral blood. Streptozotocin diabetic rats were force fed daily with palm vitamin E (200mg/kg body weight), from day three of diabetes condition established. Following eight weeks of supplementation, palm vitamin E significantly improved fasting blood glucose and glycosylated hemoglobin. The increased in plasma malondialdehyde levels were also inhibited and the levels of oxidative DNA damage of peripheral lymphocyte was reduced. This suggested that palm vitamin E has the potential in improving glycaemic status and also the protective effects against oxidative damage by inhibiting the increased in malondialdehyde and preventing DNA damage in Streptozotocin-induced diabetic rats.

Item Type:Journal
Keywords:Diabetes mellitus, palm vitamin E, antioxidant, oxidative Stress, DNA damage
Subjects:Q Science, Computer Science
R Medicine, Dentistry, Pharmacy, Nursing
ID Code:2241

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