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Effects of Palmvitee on Status of Superoxide Dismutase and Glutathione Peroxidase in Rat Liver during Aging

Looi, Mee Lee, and Noor Aini Abd Hamid, and Yasmin Anum Mohd Yusof, (2005) Effects of Palmvitee on Status of Superoxide Dismutase and Glutathione Peroxidase in Rat Liver during Aging. Malaysian Journal of Biochemistry and Molecular Biology, 12 (1). pp. 21-24. ISSN ISSN 1511-2616

Full text not available from this repository.

Official URL: http://ejum.fsktm.um.edu.my/ArticleInformation.aspx?ArticleID=607

Affiliations

Universiti Kebangsaan Malaysia. Faculty of Medicine. Dept. of Biochemistry
Universiti Kebangsaan Malaysia. Faculty of Medicine. Dept. of Biochemistry
Universiti Kebangsaan Malaysia. Faculty of Medicine. Dept. of Biochemistry

Abstract

An imbalance between production of reactive oxygen species (ROS) and its elimination by antioxidant defense system in the body has been implicated for causes of aging and neurodegenerative diseases. This study was undertaken to determine the effect of aging on the status of antioxidant enzymes such as superoxide dismutase (SOD), and glutathione peroxidase (GPx) in male Wistar rats and to evaluate the impact of palmvitee supplementation (70 % tocotrienol and 30 % tocopherol) on the antioxidant defense system. The study was conducted on young (3 months), adult (9 and 15 months) and aged (21 months) male Wistar rats fed with normal and vitamin E supplemented diets (30mg/kg rat weight/day). Low levels of SOD were found in adult rats (15 month-old: 2.90 ± 0.07 units/mg protein) and in old rats (21 month-old: 2.80 ± 0.10 units/mg protein) when compared to younger rats (3 and 9 month-old: 3.30 ± 0.16 and 3.40 ± 0.12 units/mg protein respectively). However aging had a different effect on GPx whereby an increase of GPx was observed from young to older rats with values of 0.0032 ± 0.19, 0.0071 ± 0.76, 0.0099 ± 0.50, 0.0062 ± 0.55 specific activity/mg protein for 3, 9, 15 and 21 month-old rats respectively. Supplementation with palmvitee decreased the activity of SOD in adult rats significantly when compared to non supplemented rats of the same age group, but it however did not have any effect on the activity of GPx except at the age of 15 month-old where its level was significantly lower than normal (non supplemented rats). In conclusion, palmvitee may have a protective role for both GPx and SOD by replacing or compensating their activities in rat liver.

Item Type:Journal
Keywords:superoxide dismutase, glutathione peroxidase, aging, palmvitee
Subjects:Q Science, Computer Science
R Medicine, Dentistry, Pharmacy, Nursing
ID Code:2256

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