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Functions of Human GM-CSF α-Subunit in Mediating Self-Renewal or Differentiation on FDCP-Mix Cells

Shahrul Hisham Zainal Ariffin, and Rohaya Megat Abdul Wahab, and Zaidah Zainal Ariffin, and Roslina Samsudin, and Siti Fatimah Mohd Noor, and Whetton, A.D., (2005) Functions of Human GM-CSF α-Subunit in Mediating Self-Renewal or Differentiation on FDCP-Mix Cells. Malaysian Journal of Biochemistry and Molecular Biology, 11 (1). pp. 6-12. ISSN ISSN 1511-2616

Full text not available from this repository.

Official URL: http://ejum.fsktm.um.edu.my/ArticleInformation.aspx?ArticleID=616

Affiliations

Universiti Kebangsaan Malaysia. Faculty of Science and Technology. School of Bioscience and Biotechnology
Universiti Kebangsaan Malaysia. Faculty of Dentistry. Dept. of Orthodontics
Universiti Teknologi Mara. Faculty of Applied Sciences. Dept. of Microbiology
Universiti Kebangsaan Malaysia. Faculty of Science and Technology. School of Bioscience and Biotechnology
Universiti Kebangsaan Malaysia. Faculty of Science and Technology. School of Bioscience and Biotechnology
University of Manchester. Dept. of Biomolecular Sciences

Abstract

Activation of human GM-CSF receptor ectopically expressed in polyclonal murine FDCP-Mix multipotent cells, stimulate selfrenewal or myeloid differentiation. Bioinformatic analysis revealed a potentially important tripeptide region in the α-subunits cytosolic domain. Mutation of hGM-CSF receptor α-subunit (hGM-CSFRα) involving the respective tripeptides altered the receptor function compared to the wild type receptor. The mutated hGM-CSFRα clonal cells signaled for self-renewal whilst the wild type receptor produce cell differentiations in the presence of hGM-CSF cytokines. These results showed that cytosolic region of the α-subunit was critically important for developmental decision in multipotent cell, indicating that signaling specificity for cell fate resides in the receptor’s structure.

Item Type:Journal
Keywords:GM-CSF receptor, multipotent cells, differentiation
Subjects:Q Science, Computer Science
R Medicine, Dentistry, Pharmacy, Nursing
ID Code:2266

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