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Antioxidant Potential Of Byesukar, A Polyherbal Formulation On Alloxan Induced Oxidative Stress In Rats

Guruvayoorappan C., and Sudha G., (2005) Antioxidant Potential Of Byesukar, A Polyherbal Formulation On Alloxan Induced Oxidative Stress In Rats. Malaysian Journal of Biochemistry and Molecular Biology, 11 (1). pp. 31-35. ISSN ISSN 1511-2616

Full text not available from this repository.

Official URL: http://ejum.fsktm.um.edu.my/ArticleInformation.aspx?ArticleID=620

Affiliations

Kongunadu Arts and Science College, India
Kongunadu Arts and Science College, India

Abstract

Byesukar, a polyherbal formulation intended to use for diabetic patients has been screened for antioxidant activity. For antioxidant studies, byesukar was administered orally for 30 days at a dose of 500 mg/kg body weight to alloxan induced diabetic male wistar rats. All the animals were sacrificed on the 31st day and the levels of LPO, SOD, CAT, GPx, GST and GR in kidney and liver of control and experimental rats were studied. The extracts exhibited significant antioxidant activity showing increased levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione s-transferase (GST) and glutathione reductase (GR) and decreased level of lipid peroxidation. These results showed that treatment with byesukar lowers alloxan induced LPO and alters SOD, CAT, GPx, GST and GR enzymes to reduce oxidative stress.

Item Type:Journal
Keywords:Byesukar; Alloxan; Marker enzymes in liver and kidney; Antioxidant activity
Subjects:Q Science, Computer Science
R Medicine, Dentistry, Pharmacy, Nursing
ID Code:2280

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