Synthesis and Biological Properties of Zinc(II)Complexes of some 2-hydroxyacetophenone-benzoylhydrazones
Hapipah M. Ali, and Siti Nadiah Abdul Halim, and Subramaniam, Puvaneswary, and Zain S.M., and Jefri Basirun W., and Endom Ismail, and Noorlidah Abdullah, and Teoh, H.L., (2006) Synthesis and Biological Properties of Zinc(II)Complexes of some 2-hydroxyacetophenone-benzoylhydrazones. Malaysian Journal of Science, 25 (2). pp. 97-106. ISSN 13943065 Full text not available from this repository. Official URL: http://www.ejum.fsktm.um.edu.my/ AffiliationsUniversity of Malaya. Faculty of Science. Dept. of Chemistry.
University of Malaya. Faculty of Science. Inst. of Biological Science.
National University of Malaysia. AbstractThe new zinc(II) complexes have been prepared in ethanol by condensation of 2-hydroxyacetophenone with either benzhydrazide or 3-methoxybenzhydrazide and zinc acetate in the presence of triethylamine. The IR, ¹H, ¹³C NMR and UV-visible data show coordination of hydrazone ligands to the metal centers and the spectroscopic data augur well with the x-ray structures which had been published earlier. The Schiff bases and their complexes were screened for antimicrobial, cytotoxic and antioxidant activities. The anti-microbial activities of the ligands and complexes were evaluated by using plate diffusion method against some gram-positive bacteria, gram-negative bacteria and two fungi. There was growth inhibition exhibited by ligands and zinc(II) complexes against tested bacteria and fungi. The Schiff base, H₂hapbh was cytotoxic with IC₅₀ 10.0 µgml⁻¹ against the MCF-7 (human breast cancer cells) while both zinc(II) dimer complexes were strongly cytotoxic with IC₅₀ values of 4.5 µgml⁻¹. The Schiff bases and zinc(II) complexes showed higher antioxidant activity than quercetin or vitamin E and is comparable with butylated hydroxy toluene (BHT), a commercially used synthetic antioxidant. Repository Staff Only: item control page
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