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Synthesis, Characterization and Biological Evaluation of Some Substituted Thiohydantoins

Ramachandran, S., and Nalini, C. N., and Girija, C. R., and Noor Shahina Begum, (2007) Synthesis, Characterization and Biological Evaluation of Some Substituted Thiohydantoins. Malaysian Journal of Science, 26 (2). pp. 81-89. ISSN 13943065

Full text not available from this repository.

Official URL: http://www.ejum.fsktm.um.edu.my/

Affiliations

C. L. Baid Metha College of Pharmacy. Dept. of Pharmaceutical Chemistry.
SSMRV College. Dept. of Chemistry.
Bangalore University. Dept. of Studies in Chemistry.

Abstract

Thiohydantoins have been proven to have anticonvulsant and antidepressant activity. Some derivatives of thiohydantoin containing both aryl group and benzylidene nucleus were synthesised and their anticonvulsant activity were investigated by pentylenetetrazole induced convulsions. It was found that the activity of Compound C was found to be significant when compared to that of the other three synthesized thiohydantoin compounds. Clonazepam is a marketed potent anticonvulsant drug. Compound C was compared with the clonazepam drug (0.25µg/10g).

Item Type:Journal
Keywords:Thiohydantoins, synthesis, anticonvulsant activity
Subjects:Q Science, Computer Science
R Medicine, Dentistry, Pharmacy, Nursing
ID Code:2427

1. Encylcopedia of Chemical Technology. Volume 13 (4th Edition). Kirk Othmer-514

2. Morriya, T., Hagio, K. and Yoneda, H. (1980) Facile preparation of 5-(3-indolylmethylene) hydantoins. Chem. Pharm. Bull. 28 (6): 1891 - 1893.

3. Korohoda, M. J. and Bojarska, A. B. (1976). Synthesis of 3-aryl-2-thiohydantoins and 3 arylhydantoin-5-acetic acid and screening of some of their pharmacological properties Poland J Pharmacol. Pharm. 28 (5): 423-425.

4. Rydzick, E., and Kielek, M. B. (1990). Synthesis and testing of anticonvulsant properties of 5-benzylidene derivatives of 3-ortho, 3-meta, 3-para-chlorophenyl-2 thiohydantoin. Acto. Pol. Pharm. 47 (5): 27 - 29.

5. Gesler, R. M., Lints, C. E. and Swinyard, E. A. (1961). Pharmacology of some substituted 2-thiohydantoins with particular reference to anticonvulsant properties Toxicology and Applied Pharmacology 3: 107 - 121.

6. Gesler, Iwamoto, Perker and Berger (1959). Fed. Proc. 18: 393.

7. Kulkarni, S. K. (1993). Handbook of Experimental Pharmacology. 2nd Edition, pp. 58 - 94. Vallabh Prakashan Publishers

8. King, L. Carroll (1944). Reaction of iodine with some ketones in the presence of pyridine. J. Amer. Chem. Soc. 66: 894 - 895.

9. Pandey V. K. and Manjusha Gupta (1997). Synthesis and biological activity of substituted thioimidazolidines (thiohydantoins). Indian Drugs 34 (7): 410-411.

10. Indian Pharmacoepia (1996). Volume 2, Government of India: Ministry of Health and Family Welfare (The Controller of Publication), Delhi. pp. A - 46.

11. Achary, T. E. and Nayak, A. (1972). Synthesis of 2-(2 pyridylimino-)thiazolidone and 3-(2 pyridyl-) thiohydantoin. Current Sciences 41: 539 - 540.

12. Close, W. J. and Speilman, M. A. (1961). Anticonvulsant drugs. Medicinal Chemistry 5: 1-349.

13. Tomer, R. A. (1995). Screening Methods of Pharmacology (7th Edition) Eric Press, USA. pp. 11-15 and 63.

14. Ghosh, M. N. Fundamentals of Experimental Pharmacology. Hilton and Co., Kolkata. pp. 188.

15. Goodman, L. S., Singh, G. M., Brown, W. C. and Swinyard, E. A. (1953). Comparison of maximal seizures evoked by pentylenetetrazole (metrazole) and electroshock in mice; and their modification by anticonvulsants. J. Pharmacol, Exp. Ther. 108: 168 - 176.

16. Villar, R. Laguna, M. R, Calleja, J. M. and Cadavid, I. (1992). Effects of Skeletonema costatum extracts on the central nervous system. Planta Medica 58 (5): 398 - 404.

17. Laguna, M. R., Villar, R., Cadavid, I. and Calleja, J. M. (1993). Effects of extracts of Tetraselmis suecica and Isochrysis galbana on the central nervous system. Planta Medica 59 (4): 207 - 214.

18. Goodman and Gilman (1991). The Pharmacological Basic of Therapeutics (8th Edition). pp. 454.

19. Tallarida, R. J. and Murray, R. B. (1981). Manual of Pharmacologic Calculation with Computer Programs (2nd Edition). Springer-Verlay, Heidelberg, Berlin.

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