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The protective role of zinc in palm kernel cake (PKC) toxicity in sheep

Hair-Bejo, M., and Alimon, A.R., (1995) The protective role of zinc in palm kernel cake (PKC) toxicity in sheep. Malaysian Journal of Nutrition, 1 (1). pp. 75-82. ISSN 1394-035X

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Official URL: http://nutriweb.org.my/publications/mjn001/mjn1n1_008.pdf

Affiliations

Universiti Pertanian Malaysia, Faculty of Veterinary Medicine and Animal Science

Abstract

Male Malin x Polled Dorset crossbred sheep were stall-fed with grass (10%) and PKC (90%) and supplemented with either zinc at 500 ug/g, as zinc sulfate (PKC+Zn group) or zinc (113 ug/g) and ammonium molybdate (500 ug/g) (PKC+Zn+Mo group) or unsupplemented diet (PKC group) for 20 weeks. Another group which acts as a control was fed with a diet consisting of corn and fish meal (2 0%) and grass (80%). The animals were monitored daily and the body weights were recorded at a period of two weeks intervals throughout the trial. Blood samples were also collected for mineral analysis. At the end of the trial the animals were slaughtered. The carcasses were examined for gross lesions, whilst the right liver lobes and renal cortex were isolated for histopathological evaluation and mineral analysis. All animals in the PKC group died before the end of the trial with the main clinical signs of generalised jaundice and haemoglobinuria. The kidneys were firm, enlarged and reddened or darkened. Histologically, the hepatocytes were swollen, vacuolated and necrotized, particularly at the periacinar zone. Hepatic fibrosis was observed at the periportal zone. Cellular swelling, vacuolation and necrosis were found in the tubular epithelial cells of the renal cortex. Neither clinical signs nor gross or remarkable histological lesions were observed in the other groups of animals. The hepatic, renal and blood copper levels In the PKC group were elevated when compared to the control. Addition of zinc either with or without ammonium molybdate in PKC diet inhibit the copper content in the organs, however the zinc contents were increased. The average daily gain of the PKC group was remained consistent to those of the other groups, except it was reduced starting at about 1 to 2 weeks prior to death. It was concluded that feeding PKC In excess in sheep can cause chronic copper toxicity. However, this effect can be prevented by dietary zinc supplementation either with or without ammonium molybdate.

Item Type:Journal
Additional Information:This note was added by the search_and_modify.pl script.
Keywords:Crossbred Sheep, Palm Kernel Cake (PKC), Histopathology
Subjects:R Medicine, Dentistry, Pharmacy, Nursing
ID Code:2557

1. Abdul Rahman M.Y., Wong H.K., Zaini H & Sharif H (1989). Preliminary observation on the alleviation of copper in sheep fed with palm kernel meal based diet. Proc of 12 Conf MSAP pp 75-78.

2. Bremner 1 (1980). Absorption, transport and distribution of copper. In Biological Roles of Copper, Ciba Foundation Symphosium 79, eds Evered & G Lawrenson, pp 23-48, Excerpts Medica: Amsterdam, Oxford, New York.

3. Brewer GJ, Hill GM, Prasad AS, Cossack ZT & Rabbani P (1983). Oral zinc therapy for Wilson’s disease. Ann Int Med 99:314-320.

4. Cousins RJ (1985). Absorption, transport and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmln. Physiol Rev 65(2):238-309.

5. Evans GW (1973). Copper homeostasis in the mamalian system. Physiol Rev 53(3):535-570.

6. Goonerathne SR. Howel JMCC & Gawthome JM (1981). Intravenous administration of thiomolybdate for prevention and treatment of chronic copper poisoning in sheep. Br J Nutr 46:457-467.

7. Hair-Bejo M, Haywood S & Trafford J (1991). Dietary zinc supplementation: An alternative therapy for copper toxicosis. The 3rd Congress of the Veterinary Association Malaysia pp 59-61.

8. Haywood 5, Rutgers HC & Christian MK (1988). Hepatitis and copper accumulation in Sky Terriers. Vet Pathol 25:408-414.

9. Higgins RJ (1981). Chronic copper poisoning in growing pigs. Vet Rec 109:134- 135.

10. Ishmael J, Gopinath C & Howel JMCC (1971). Experimental chronic copper toxicity in sheep: Histological and histochemical changes during development of the lesions in the liver. Res Vet Sci 12:358-366.

11. Jalaludin S. Jelan Z.A., Abdullah N & How Y.W. (1991). Recent developmants in the oil palm by-product based ruminant feeding system. In Recent Advances on the Nutrition of Herbivores, eds YW How et al., pp 35-44, MSAP.

12. LillIe RD (1965). Nuclei, nucleic acids, general oversight stains. In Hlstopathotogic Technic and Practical Histochemistry, 3rd edition pp 142-179, Mc Graw Book Company.

13. Marschang F, Timme A, Baum A & Morscher H (1980). Copper poisoning in cattle as a herd problem; possibilities of early recognition, prophylaxis, and metaphylaxis. Vet Med Review 2:155-167.

14. Mehra RK & Breamer 1 (1984). Species differences in the occurance of coppermetallothionein in the particulate fractions of liver of copper loaded animals. Biochem J 2 19:539-546.

15. Mill CF (1980). Metabolic interactions of copper with other trace elements. In Biological Roles of Copper, Ciba Foundation Symphosium 79, eds D Evered & 0 Lawrenson, pp 49-69, Excerpta Medica: Amsterdam, Oxford, New York.

16. Oestreicher P & Cousins RJ (1985). Copper and zinc absorption in rat: Mechanism of mutual antagonism. J Nutr 115:159-166.

17. Rafferty J, Norling R, Mc Math C, Tamaru R & Morganstein D (1985). Statwork (version 1.1), Heyden and Son, Ltd.

18. Scheinberg IH & Sternlieb 1 (1976). Copper toxicity and Wilson’s disease. In Trace Elements in Human Health and Diseases, Vol 1, pp 415-438, New York, Academic Press.

19. Soli NE (1980). Chronic copper poisoning in sheep. A review of the literature. Nord Vet Med 32:75-80.

20. Twedt DC, Stemlieb I & Gilbertson SR (1979). Clinical, morphologic, and chemical studies on copper toxicosis of Bedlington terriers. J Am Vet Med Ass 175(3):269-275.

21. Underwood EJ (1977). Copper. In Trace Elements in Human and Animal Nutrition. 4th edition, pp 56-108, New York, San Fracinsco, London, Academic press.

22. Wan Mohamed W.E., Abdul Rahman A, Mobamad N & Koh H.F. (1989). Oil palm byproducts in prime lamb production. Proc of 12th Conf MSAP pp 69-74

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