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Chemical Composition and Biological Activity of the Centipeda minima (Asteraceae)

Soetardjo, Surjani, and Jong, Poh Chan, and Ahmad Mohamad Noor, and Lachimanan, Yoga Latha , and Sreenivasan, Sasidharan , (2007) Chemical Composition and Biological Activity of the Centipeda minima (Asteraceae). Malaysian Journal of Nutrition, 13 (1). pp. 81-87. ISSN 1394-035X

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Official URL: http://nutriweb.org.my/publications/mjn0013_1/mjn13n1_art8.pdf

Affiliations

Universiti Sains Malaysia, School of Distance Education
Universiti Sains Malaysia, School of Chemical Sciences
Universiti Sains Malaysia, School of Biological Sciences

Abstract

The antimicrobial activity of the Centipeda minima L. (Asteraceae) extract was evaluated against seven microorganisms using the disc diffusion method. The extract showed a broad spectrum of antimicrobial activity against all the tested bacterial strains, especially Enterobacter aerogenes, Klebsiella pneumonia, Staphylococcus aureus and Yersinia enterocolitica. The chemical composition of the extract obtained from Centipeda minima was analysed by GC–MS. Twentythree compounds, constituting about 84.75 % of the total extract, were identified. The main constituents were palmitic acid (7.47%), (Z,Z)-9-,12-octadecatrienoic acid (6.52%), (Z,Z,Z)-9-,12-octadecatrienoic acid (7.01%), phytol (7.01%), naptho[2.3-b]furan-2-(3H)-on (6.21%), 1-(1,2,3,4,7,7a-hexahydro-1,4,4,5-tetramethyl-1,3a-ethano-3aH inden-6-yl)etanon (7.95%), 1,3,5-tri-tertbutyl- benzene (4.52%), (3Z)-2-methyl-3-octen-2-ol (5.95%) and artemisia ketone (4.98%). The extract was also tested against brine shrimp for toxicity. There was no significant toxicity as it only recorded a LC50 value of 4.92 mg/ml. The study shows that the extract is a good antimicrobial agent with potential applications in public health against diseases.

Item Type:Journal
Keywords:Centipeda minima (Asteraceae)
Subjects:R Medicine, Dentistry, Pharmacy, Nursing
ID Code:3093

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