The Effects of Repeatedly Heated Frying Oil and High Cholesterol Diet on the Bone in Ovariectomised Rats
Nazrun A.S., and Chew, C.M., and Norazlina M., and Kamsiah J., and Ima Nirwana S., (2007) The Effects of Repeatedly Heated Frying Oil and High Cholesterol Diet on the Bone in Ovariectomised Rats. Malaysian Journal of Nutrition, 13 (1). pp. 89-99. ISSN 1394-035X
Official URL: http://nutriweb.org.my/publications/mjn0013_1/mjn13n1_art9.pdf
Universiti Kebangsaan Malaysia, Faculty of Medicine, Dept. of Phamacology
Universiti Kebangsaan Malaysia, Faculty of Allied Health Sciences, Dept. of Biomedical Sciences
The use of repeatedly heated frying oils and intake of high cholesterol diet have been linked to bone damage. The aim of this study is to determine the combined effects of taking repeatedly heated frying oils (palm or soy oil) and high cholesterol diet on the dynamic histomorphometric parameters of bone. Ovariectomised rats were used as animal model of post-menopausal osteoporosis. After six months of treatment, Double-labeled Surface (dLS/BS), Mineralising surface (MS/BS) and Bone Formation Rate (BFR/BS) of ovariectomised rats (OvxC) were significantly reduced compared to the normal control group. Additions of fresh or once-heated palm or soy oil into high cholesterol diet seem to have improved the dynamic parameters towards the normal control values. However, when these oils were repeatedly heated, the protective effects were lost and the dynamic parameters except MS/BS dropped back towards the ovariectomised-control values.
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