Author, Subjects, Keywords

Cited Author

 
 
   » By Author or Editor
 » Browse Author by Alphabet
 » By Journal
 » By Subjects
 » Malaysian Journals
 » By Type
 » By Year
 » By Latest Additions
 
 
   » By Author
 » Top 20 Authors
 » Top 20 Article
 » Top Journal Cited
 » Top Article Cited
 » Journal Citation Statistics
 » Usage Since Sept 2007


 
 
 

Login | Create Account

Etiology of blood culture isolates among patients in a multidisciplinary teaching hospital in Kuala Lumpur

Karunakaran, Rina, and Raja, Nadeem Sajjad, and Ng, K.P., and Navaratnam, Parasakthi, (2007) Etiology of blood culture isolates among patients in a multidisciplinary teaching hospital in Kuala Lumpur. Journal of Microbiology, Immunology and Infection , 40 (5). pp. 432-437.

Full text not available from this repository.

Affiliations

University of Malaya. Faculty of Medicine. Dept. of Medical Microbiology
University of Malaya. Faculty of Medicine. Dept. of Medical Microbiology
University of Malaya. Faculty of Medicine. Dept. of Medical Microbiology
University of Malaya. Faculty of Medicine. Dept. of Medical Microbiology

Abstract

Bloodstream infections are an important cause of morbidity and mortality among hospitalized patients and the surveillance of etiological agents in these infections is important for their prevention and treatment. Data on common organisms isolated from blood cultures from Malaysia are limited, and our aim was to identify the common bloodstream isolates in hospitalized patients at the University of Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia. A retrospective analysis was conducted over a 1-year period from January to December 2004 by reviewing laboratory reports of patients from the UMMC. The clinical significance of the isolates was not analyzed. Coagulase-negative staphylococci were the most common organisms isolated, accounting for 33.0% of the total blood culture isolates, followed by Staphylococcus aureus (10.4%) and Escherichia coli (9.7%). The incidence of methicillin-resistant S. aureus, and extended-spectrum beta-lactamase-producing E. coli and Klebsiella spp. bacteremia was low (2.3% and 1.8% of total isolates, respectively). Non-albicans Candida were the most common fungal isolates. Conclusions: The high number of coagulase-negative staphylococci should motivate clinicians and microbiologists to re-examine blood culture techniques in our institution. We recommend that further studies be carried out to establish the true significance of this organism among blood culture isolates.

Item Type:Journal
Keywords:Bacteremia; Etiology; Hospitals; Retrospective studies, bloodstream infections
Subjects:R Medicine, Dentistry, Pharmacy, Nursing
ID Code:3364

1. Reimer LG, Wilson ML, Weinstein MP. Update on detection of bacteremia and fungemia. Clin Microbiol Rev.1997;10:444-65.

2. Weinstein MP, Reller LB, Murphy JR, Lichtenstein KA. The clinical significance of positive blood cultures: a comprehensive analysis of 500 episodes of bacteremia and fungemia in adults.I. Laboratory and epidemiologic observations. Rev Infect Dis.1983;5:35-53.

3. Jarlier V, Nicolas MH, Fournier G, Philippon A. Extended broad-spectrum beta-lactamases conferring transferable resistance to newer beta-lactam agents in interobacteriaceae: hospital prevalence and susceptibility patterns. Rev Infect Dis. 1988;10:867-78.

4. Souvenir D, Anderson DE, Palpant S, Mroch H, Askin S, Anderson J, et al. Blood cultures positive for coagulase-negative staphylococci: antisepsis, pseudobacteremia, and therapy of patients. J Clin Microbiol. 1998;36:1923-6.

5. Towns ML, Quartey SM, Weinstein MB, Reimer LG, Reller LB. The clinical significance of positive blood cultures: a prospective, multicenter evaluation. In: Abstracts of the 93rd General Meeting of the American Society for Microbiology, C-232. Washington, DC: American Society for Microbiology; 1993.

6. Weinstein MP, Towns ML, Quartey SM, Mirrett S, Reimer LG, Parmigiani G, et al. The clinical significance of positive blood cultures in the 1990s: a prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults. Clin Infect Dis. 1997;24:584-602.

7. Weinstein MP, Mirrett S, Van Pelt L, McKinnon M, Zimmer BL, Kloos W, et al. Clinical importance of identifying coagulase-negative staphylococci isolated from blood cultures: evaluation of MicroScan Rapid and dried overnight Grampositive panels versus a conventional reference method. J Clin Microbiol. 1998;36:2089-92.

8. Collignon P, Nimmo GR, Gottlieb T, Gosbell IB. Staphylococcus aureus bacteremia, Australia. Emerg Infect Dis. 2005; 11:554-61.

9. Livermore DM. Bacterial resistance: origins, epidemiology, and impact. Clin Infect Dis. 2003;36:S11-23.

10. Kim YK, Pai H, Lee HJ, Park SE, Choi EH, Kim JH, et al. Bloodstream infections by extended-spectrum beta-bactamaseproducing Escherichia coli and Klebsiella pneumoniae in children: epidemiology and clinical outcome. Antimicrob Agents Chemother. 2002;46:1481-91.

11. Tumbarello M, Spanu T, Sanguinetti M, Citton R, Montuori E, Leone F, et al. Bloodstream infections caused by extendedspectrum-beta-lactamase-producing Klebsiella pneumoniae: risk factors, molecular epidemiology, and clinical outcome. Antimicrob Agents Chemother. 2006;50:498-504.

12. Sharp SE. Routine anaerobic blood cultures: still appropriate today? Clin Microbiol Newsl. 1991;13:179-81.

13. Beck-Sagué C, Jarvis WR. Secular trends in the epidemiology of nosocomial fungal infections in the United States, 1980-1990. National Nosocomial Infections Surveillance System. J Infect Dis. 1993;167:1247-51.

14. Akbar DH, Tahawi AT. Candidemia at a university hospital: epidemiology, risk factors and predictors of mortality. Ann Saudi Med. 2001;21:178-182.

15. Diekema DJ, Messer SA, Brueggemann AB, Coffman SL, Doern GV, Herwaldt LA, et al. Epidemiology of candidemia: 3-year results from the emerging infections and the epidemiology of Iowa organisms study. J Clin Microbiol. 2002;40:1298-302.

16. Pfaller MA, Jones RN, Doern GV, Sader HS, Messer SA, Houston A, et al. Bloodstream infections due to Candida species: SENTRY Antimicrobial Surveillance Program in North America and Latin America, 1997-1998. Antimicrob Agents Chemother. 2000;44:747-51.

Repository Staff Only: item control page
 
 
 
 
 
 
© Copyright 2007 MyAIS Faculty of Computer Science and Information Technology, University of Malaya – All Rights Reserved. Malaysian Abstracting and Indexing System is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.