Author, Subjects, Keywords

Cited Author

 
 
   » By Author or Editor
 » Browse Author by Alphabet
 » By Journal
 » By Subjects
 » Malaysian Journals
 » By Type
 » By Year
 » By Latest Additions
 
 
   » By Author
 » Top 20 Authors
 » Top 20 Article
 » Top Journal Cited
 » Top Article Cited
 » Journal Citation Statistics
 » Usage Since Sept 2007


 
 
 

Login | Create Account

Proliferating Cell Nuclear Antigen (PCNA) Expression in Oral Squamous Cell Carcinoma - An Aid to Conventional Histological Grading?

Zain, R B, and Sakamoto, F, and Shrestha, P, and Mori, M, (1995) Proliferating Cell Nuclear Antigen (PCNA) Expression in Oral Squamous Cell Carcinoma - An Aid to Conventional Histological Grading? Malaysian Journal of Pathology, 17 (1). pp. 23-30. ISSN 0126-8635

Full text not available from this repository.

Official URL: http://www.mjpath.org.my/past_issue/MJP1995.1/proliferating%20cell%20nuclear%20antigen%20expression.pdf

Affiliations

University of Malaya, Faculty of Dentistry. Dept. of Oral Pathology, Oral Medicine and Periodontology, ["lib/metafield:join_corp_creators" not defined]Asahi University, Japan, School of Dentistry. Dept. of Oral and Maxillofacial Surgery ["lib/metafield:join_corp_creators" not defined]Asahi University, Japan, School of Dentistry. Dept. of Oral and Maxillofacial Surgery ["lib/metafield:join_corp_creators" not defined]Asahi University, Japan, School of Dentistry. Dept. of Oral and Maxillofacial Surgery

Abstract

Proliferating cell nuclear antigen (PCNA) is a well known marker for cell proliferation. It tends to accumulate in the late G, and S-phase of the cell cycle. A monoclonal antibody (MoAb) against PCNA is now available and it can react with paraffin-embedded specimens. In the present study, PCNA immunohistochemical staining of 36 cases of oral cancer specimens obtained from surgery were investigated. The results showed differing nuclear staining patterns for PCNA in normal, hyperplastic and dysplastic epithelium, early cancer and 3 levels of differentiation for squamous cell carcinoma of the oral cavity. It appears that PCNA can be a useful marker in delineating normal epithelium and hyperplastic epithelium from dysplasia in the oral cavity. The use of PCNA staining may further emphasize the conventional histopathological grading of well-differentiated, moderately-differentiated and poorly-differentiated oral squamotls cell carcinoma but is still dependent on basic criteria as observed without immunostaining. PCNA expression for all grades of squamous cell carcinoma are present at the deep, infiltrative margins.

Item Type:Journal
Additional Information:This note was added by the search_and_modify.pl script.
Keywords:Proliferating cell nuclear antigen, oral cancer, oral precancer, histopathological grading.
Subjects:R Medicine, Dentistry, Pharmacy, Nursing
ID Code:3579

1. Regezi JA, Sciubba JJ. Oral Pathology. Clinico-Pathologic Correlations. WB Saunders Company, Philadelphia 1989; pg 70-82,94-99.

2. Willtn R, Nathanson A, Moberger G, Anneroth G. Squamous cell carcinoma of the gingiva. Histological classification and grading of malignancy. Acta Otolaryngol 1975; 79:146-54.

3. Miyachi K, Fritzler MJ, Tan EM. Autoantibodies to a nuclear antigen in proliferating cells. J Imrnunol 1978; 121: 2228-34.

4. Bravo R, Bravo HM. Existence of two population of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites. J Cell Biol 1987; 105: 1549-54.

5. Landberg G, Tan EM, Roos G. Flow cytometric multiparameter analysis of proliferating cell nuclear antigen/cyclin and Ki-67 antigen: a new view of the cell cycle. Exp Cell Res 1990; 187: 11 1-8.

6. Tsuji T, ShresthaP, YamadaK, Takagi H, Shinozaki F, Sasaki K, Maeda K, Mori M. Proliferating cell nuclear antigen in malignant and premalignant lesions of epithelial origin in the oral cavity and the skin: an immunohistochemical study. Virchows Archiv A Pathol Anat 1992; 420: 377-83.

7. Tsuji T, Sasaki K, Kimura Y, Yamada K, Mori M,Shinozaki F. Measurement of proliferating cell nuclear antigen (PCNA) and its clinical implication in oral cancers. Int J Oral Maxillofac Surg 1992; 21:369-72.

8. Coltrera MD, Zarbo RJ, Sakr WA, Gown AM. Markers for dysplasia of the upper aerodigestive tract. Suprabasal expression of PCNA, p53, and CK 19 in alcohol-fixed, embedded tissue. Am J Pathol 1992; 141(4): 817-25.

9. Warnakulasuriya KAAS, Johnson NW. Association of overexpression of p53 oncoprotein with the state of cell proliferation in oral carcinoma. J Oral Pathol Med 1994; 23: 246-50.

10. Shan-Rong S, Marc EK, Krishnan LK. Antigen retrieval in formalin-fixed, parraffin-embedded tissues: An enhancement method for imrnunohistochemical staining based on microwave oven heating of tissue sections. J Histochem & Cytochem 1991; 39(6): 741-8.

11. WHO collaborating centre for oral precancerous lesions. Definition of leukoplakia and related lesions: An aid to studies on oral precancer. Oral Surg 1978; 46(4): 518-39.

12. Anneroth G, Hansen LS. A methodologic study of histologic classification and grading of malignancy in oral squamous cell carcinoma. Scand J Dent Res 1984; 92: 448-68.

13. Pindborg JJ, Reibel J, Holmstrup P. Subjectivity in evaluating oral epithelial dysplasia, carcinoma in situ and initial carcinoma. J Oral Pathol 1985; 14: 698-708.

14. Jakobssen PA. Eneroth C-M, Killander D, Moberger G, M2rtensson B. Histologic classification and grading of malignancy in carcinoma of the larynx (a pilot study). Acta Radiol Ther Phys Biol 1973; 12: 1-8.

15. Byrne M, Koppang HS, Lilleng R, Kjaerheim A.Malignancy gradi~igo f the deep invasive margins of oral squamous carcinomas has high prognostic value. J Pathol 1992; 166: 375-81.

16. Al-Sheneber IF, Shibata HR, Sampalis J, Jothy S.

Prognostic significance of proliferating cell nuclear antigen expression in colorectal cancer. Cancer 1993; 71: 1954-9.

17. Yonemura Y, Kimura H, Fushida S, Tugawa K, Nakai Y, Kaji M, Fonseca L, Yamaguchi A, Miyazaki I. Analysis of proliferative activity using anti-proliferating cell nuclear antigen antibody in gastric cancer tissue specimens obtained by endoscopic biopsy. Cancer 1993; 71: 2448-53.

18. Munck-Wikland E, Femberg J-0, Kuylenstiema R, Lindholm J, Auer G. Proliferating cell nuclear antigen (PCNA) expression and nuclear DNA content in predicting recurrence after radiotherapy of early glottic cancel. Oral Oncol Eur J Cancer 1993; 29b(l): 75-9.

Repository Staff Only: item control page
 
 
 
 
 
 
© Copyright 2007 MyAIS Faculty of Computer Science and Information Technology, University of Malaya – All Rights Reserved. Malaysian Abstracting and Indexing System is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.