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Analysis of Nifedipine Content in Transdermal Drug Delivery- system Using Non-destructive Visible Spectrophotometry Technique.

Normaizira Hamidi, and Mohd Nasir Taib, and Wong, Tin Wui, (2008) Analysis of Nifedipine Content in Transdermal Drug Delivery- system Using Non-destructive Visible Spectrophotometry Technique. Malaysian Journal of Analytical Sciences, 12 (2). pp. 348-351. ISSN 13942506

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Official URL: http://pkukmweb.ukm.my/~mjas/v12_n2/Normaizira%20Hamidi.pdf

Affiliations

Universiti Teknologi MARA, Faculty of Pharmacy, Particle Design Research Group
Universiti TeknoUniversiti Teknologi MARA, Faculty of Electrical Engineeringlogi. Non-Destructive Biomedical and Pharmaceutical Research Centre
Universiti Teknologi MARA, Faculty of Pharmacy, Particle Design Research Group

Abstract

The applicability of visible spectrophotometry technique as a tool to determine the drug content of polymeric film for use as a transdermal drug delivery system was investigated. Hydroxypropylmethycellulose (HPMC) was selected as the matrix polymer and nifedipine as the model drug. Blank and nifedipine-loaded HPMC films were prepared using the solvent
evaporation method. The absorbance spectra of these films under the visible wavelengths between 400 and 800 nm were
assessed and compared against the drug content values obtained by means of the conventional destructive UVspectrophotometry technique. The latter required the use of a solvent system which contained methanol, a harmful organic component in pharmaceutical applications. The results indicated that the absorbance values, attributed to nifedipine, at the wavelengths of 545, 585, 638 and 755nm were significantly correlated to the drug content values obtained using the chemical assay method (Pearson correlation value: r ≥ 0.990 and p < 0.01). The visible spectrophotometry technique is potentially suitable for use to determine the nifedipine content of films owing to its nature of characterization of transdermal drug delivery system which does not require sample destruction during the process of measurement. The samples are recoverable from test and analysis of the entire batch of samples is possible without the need of solvents and chemical reagents.

Item Type:Journal
Keywords:Hydroxypropylmethycellulose; Nifedipine; Visible Spectrophotometry; UV Spectrophotometry
Subjects:Q Science, Computer Science
ID Code:4055

1. Anuar N.K., Wong,T.W., Ghodgaonkar, D.K. and Taib M.N. 2007. Characterization of hydroxypropylmethylcellulose films using microwave non-destructive testing technique. Journal of Pharmaceutical and Biomedical Analysis, 43 , pp549-557.

2. X. Zhan, G. Tang, S. Chen and Z. Mao. 2006. A new copolymer membrane controlling clonidine linear release in a transdermal drug delivery system. International Journal of Pharmaceutics, 322, pp 1-5.

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