Some nitrogen sulfur compounds: Bondings and biological properties

Tarafder, M.T.H., and Saravanan, N., and Ali A.M., and Kasbollah, A., and Crouse, K.A., and Yih, K.Y., (2001) Some nitrogen sulfur compounds: Bondings and biological properties. Asia Pacific Journal of Molecular Biology & Biotechnology, 9 (1). pp. 38-44.

Full text not available from this repository.

Affiliations

Universiti Putra Malaysia. Dept. of Chemistry
Universiti Putra Malaysia. Dept. of Chemistry
Universiti Putra Malaysia. Dept. of Biotechnology
Universiti Putra Malaysia. Dept. of Chemistry
Universiti Putra Malaysia. Dept. of Chemistry
Universiti Putra Malaysia. Dept. of Chemistry

Abstract

Eleven Schiff bases with different functionalities were prepared from the condensation of S benzyldithiocarbazate (SBDTC) with aldehydes and ketones. Six of these bases had been prepared previously but had not been tested for biological activity. They were chosen because of the variation in biological activity that might be afforded by the different substituent groups. These were all straight chain compounds. The condensation products of 2,3 butanedione were also straight chain derivatives, however, the interactions between acetylacetone, benzoyl chloride and ethyl benzoyl acetate yielded cyclic aromatic compounds. All of the compounds were characterized using elemental analyses and other physico chemical techniques. SBDTC and its Schiff bases were screened for antimicrobial and cytotoxic activities. Although only the S benzyldithiocarbazate showed antimicrobial activity, both it and some of its Schiff bases were cytotoxic to varying degrees.

Item Type:

Journal

Keywords:

Nitrogen sulphur compounds, cyclization of Schiff bases, antimicrobial activity, cytotoxicity

Subjects:

Q Science, Computer Science

ID Code:

4086