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A Novel Therapy for the Treatment of Pyoderma Gangrenosum

Azizan N.Z., and Gangaram, H.B., and Hussein S.H., (2008) A Novel Therapy for the Treatment of Pyoderma Gangrenosum. Medical Journal of Malaysia, 63 (1). pp. 51-54. ISSN 0300-5283

Full text not available from this repository.

Affiliations

Hospital Kuala Lumpur. Dept. of Dermatology.
Hospital Kuala Lumpur. Dept. of Dermatology.
Hospital Kuala Lumpur. Dept. of Dermatology.

Abstract

Pyoderma gangrenosum (PG) is an uncommon, chronic, painful, ulcerative skin disease of unknown origin, often associated with systemic diseases, including inflammatory bowel disease, rheumatoid arthritis, monoclonal gammopathy, hepatitis and myeloproliferative disorders. The mainstay of therapy for PG has been high dose corticosteroids but not all patients have a favourable outcome. Other systemic agents have also been used such as cyclosporine, azathioprine, cyclosphamide and tacrolimus. However, all these systemic therapies can be complicated by serious side effects. In this Paper, we report a series of four patients with pyoderma gangrenosum treated successfully with topical cyclosporine. No side effects were observed in any of the patients and there was minimal systemic absorption of the topical cyclosporine.

Item Type:Journal
Subjects:R Medicine, Dentistry, Pharmacy, Nursing
ID Code:4256

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