Author, Subjects, Keywords

Cited Author

 
 
   » By Author or Editor
 » Browse Author by Alphabet
 » By Journal
 » By Subjects
 » Malaysian Journals
 » By Type
 » By Year
 » By Latest Additions
 
 
   » By Author
 » Top 20 Authors
 » Top 20 Article
 » Top Journal Cited
 » Top Article Cited
 » Journal Citation Statistics
 » Usage Since Sept 2007


 
 
 

Login | Create Account

GnRH Agonist and GnRH Antagonist in Intracytoplasmic Injection Cycles

Zainul Rashid M.R., and Ong, F.B., and Omar M.H., and Ng, S.P., and Nurshaireen A., and Sharifah Teh N.S.M.N., and Fazilah A.H., and Zamzarina M.A., (2008) GnRH Agonist and GnRH Antagonist in Intracytoplasmic Injection Cycles. Medical Journal of Malaysia, 63 (2). pp. 113-117. ISSN 0300-5283

Full text not available from this repository.

Affiliations

Universiti Kebangsaan Malaysia. Medical Faculty. Dept. of O & G.
Universiti Kebangsaan Malaysia. Medical Faculty. Dept. of O & G.
Universiti Kebangsaan Malaysia. Medical Faculty. Dept. of O & G.
Universiti Kebangsaan Malaysia. Medical Faculty. Dept. of O & G.
Universiti Kebangsaan Malaysia. Medical Faculty. Dept. of O & G.
Universiti Kebangsaan Malaysia. Medical Faculty. Dept. of O & G.
Universiti Kebangsaan Malaysia. Medical Faculty. Dept. of O & G.
Universiti Kebangsaan Malaysia. Medical Faculty. Dept. of O & G.

Abstract

The long agonistic protocol for controlled ovarian hyperstimulation (COH) is effective and used most often, thus is considered the gold standard. Therefore any new regimen has to be compared in its results with those obtained with the long protocol. This report compares the efficacy of GnRH agonist and antagonist in a retrospective study of IVF/ICSI carried out in a tertiary teaching hospital from 2003 to 2006. Only the first COH cycle followed by IVF-ICSI from 200 couples (agonist=120 and antagonist=80) were analyzed. The end points studied included the number of oocytes recovered, number of mature (MII) oocytes, fertilization, cleavage, morphology based embryo quality, pregnancy rate, quantity and cost of gonadotrophin. The average age of female subjects was 35.1 ± 4.7 years with 50% being 35 years and above. Major infertility factors were tubal blockage, male factor and endometriosis altogether comprising 68%. GnRH agonist and antagonist cycle parameters were comparable except lesser amount of gonadotrophn was used with lower resultant costs (both p < 0.0005) in antagonistic regime. Antagonist regime produce somewhat more good quality embryos (p = 0.065), an insignificant difference. A clinical pregnancy rate per embryo transfer of 16.3% in agonist and 20.6% in antagonist regime was achieved respectively. In conclusion, GnRH antagonist protocol produced a COH response, embryonic development and pregnancy rates on par to GnRH agonist regime. Moreover GnRH antagonist protocol required a shorter stimulation period plus fewer complications. Hence GnRH antagonist regime provided means for a friendlier, convenient and cost effective protocol for patients.

Item Type:Journal
Keywords:Ovarian Stimulation, GnRH Agonist, GnRH Antagonist, Assisted Reproduction, Intracytoplasmic Sperm Injection
Subjects:R Medicine, Dentistry, Pharmacy, Nursing
ID Code:4264

1. Lunenfeld E. Application of GnRH analogues in the management of female infertility. In: Lunenfeld E (eds) GnRH analogues: the state of the ART at the millennium. A summary of the 5th International Symposium on GnRH Analogues in Cancer and Human Reproduction, Geneva. London: Parthenon Publishing Group, 1999; 65-72.

2. de Jong D, Macklon NS, Fauser BCJM. Current status of GnRH antagonist in ART. In Allahbadia GN (ed) Manual of Ovulation Induction. New Delhi: Jaypee Brothers Medical Publishers (P) Ltd. 2003; 230-41.

3. Felderbaum RE, Diedrich K. The use of GnRH antagonist in assisted reproduction technologies. In: Lunenfeld E (eds) GnRH analogues: the state of the ART at the millennium. A summary of the 5th International Symposium on GnRH Analogues in Cancer and Human Reproduction, Geneva. London: Parthenon Publishing Group, 1999; 47-64.

4. Al-Inany H, Aboulgar M. GnRH antagonist in assisted reproduction: a Cochrane review. Hum Reprod 2002; 17: 874-85.

5. Griesinger G, Felberbaum R, Diedrich K. GnRH antagonists in ovarian stimulation: a treatment regimen of clinicians’s second choice? Data from the German national IVF registry. Hum Reprod 2005; 20: 2372-75.

6. van Loenen ACD, Huirne JAF, Schats K, Hompes PGA, Lambalk CB. GnRH agonists, antagonists, and assisted conception Semin Reprod Med 2002; 20: 349-64.

7. World Health Organization. WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction (4th ed.) Cambridge: Cambridge University Press, 1999.

8. Allahbadia G, Basuray R (eds) The art and science of assisted reproductive techniques (ART). London: Taylor and Francis, 2004.

9. Lindhem SR and Morales AJ. Gn RH antagonist followed by decline in serum estradiol results in adverse outcomes in donor oocytes cycles. Hum Reprod 2003; 18: 2048-51.

10. Ricciarelli E, Sanchez M, Martinez M, et al. Impact of gonadotrophin-releasing hormone antagonist in oocytes donation cycles. Fertil Steril 2003; 79: 1461-63

11. Panzan M, Motta ELA, Olive DL, et al. Poor responders in assisted reproductive technology: a blue print for management. In Allahbadia GN (ed) Manual of Ovulation Induction. New Delhi: Jaypee Brothers Medical Publishers (P) Ltd. 2003; 207-22.

12. Takahashi K, Mukaida T, Tomiyama T, et al. GnRH antagonist improved blastocyst quality and pregnancy outcome after multiple failures of IVF/ISCI-ET with GnRH agonist protocol. J Assist Reprod Genet. 2004; 21: 317-22.

13. Baart FB, Martini E, Eijkemans MJ et al. Milder ovarain stimulation for in- vitro fertilization reduces aneuploidy in the human preimplantation embryo: a randomized controlled trial. Hum Reprod 2007; 22: 980-88.

14. Jones HWJ, Out HJ, Hoomans EH, Driessen SG, et al. Cryopreservation: the practicalities of evaluation. Hum Reprod 1997; 12: 1522-24.

Repository Staff Only: item control page
 
 
 
 
 
 
© Copyright 2007 MyAIS Faculty of Computer Science and Information Technology, University of Malaya – All Rights Reserved. Malaysian Abstracting and Indexing System is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.