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Outcome of Moderate to Severe Malnutrition following Persistent Diarrhoea – A Hospital Based Retrospective Study

Lee, W.S., and Gan, C.S., and Chai, P.F., and Harun F., (2008) Outcome of Moderate to Severe Malnutrition following Persistent Diarrhoea – A Hospital Based Retrospective Study. Medical Journal of Malaysia, 63 (3). pp. 229-236. ISSN 0300-5283

Full text not available from this repository.

Affiliations

University of Malaya Medical Centre. Dept. of Paediatrics.
University of Malaya Medical Centre. Dept. of Paediatrics.
University of Malaya Medical Centre. Dept. of Paediatrics.
University of Malaya Medical Centre. Dept. of Paediatrics.

Abstract

We aimed to determine the outcome of nutritional intervention in children with moderate to severe malnutrition following persistent diarrhoea (PD), referred to a tertiary referral unit in Malaysia. Thirty one (44%) of the 71 children (median age 19 months) with PD had moderate to severe malnutrition on admission. Fifty three (75%) required dietary modification and 15 (21%) needed parenteral nutrition (PN, median duration 96 days). Of the 70 patients in whom remission of diarrhoea could be ascertained, 64 (91%) achieved remission. Three required home PN. At three months after discharge, there was a significant improvement in the mean weight for height z-score as compared to the original score at initial presentation (from –1.83 ± 1.77 to –0.80 ± 1.17; p < 0.001), although 12 (22%) of the 55 patients in whom nutritional status could be ascertained still had moderate to severe malnutrition. In conclusion, moderate to severe malnutrition was a common complication following PD resulting from diverse causes. With appropriate therapy, remission can be achieved in majority of patients, although a small number of patients needed home PN because of persistance of diarrhoea.

Item Type:Journal
Additional Information:The authors wish to acknowledge Professor CCM Boey for reading the manuscript, and the assistance of Professor IW Booth, Institute of Child Health, Birmingham Children’s Hospital, Birmingham, United Kingdom, for helping to arrange electron microscopic examination of some of the small bowel biopsy in arriving the diagnosis, particularly cases of microvillous inclusion disease and persistent diarrhoea with phenotypic abnormalities.
Keywords:Persistent diarrhoea, Malnutrition, Nutritional intervention
Subjects:R Medicine, Dentistry, Pharmacy, Nursing
ID Code:4283

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