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CT Perfusion as a Useful Tool in the Evaluation of Leuko-araiosis

Ramli N., and Ho, K.L., and Nawawi O., and Chong, H.T., and Tan, C.T., (2006) CT Perfusion as a Useful Tool in the Evaluation of Leuko-araiosis. Biomedical Imaging and Intervention Journal, 2 (2).

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Official URL: http://www.biij.org/2006/2/e16/e16.pdf

Affiliations

University of Malaya Medical Centre, Dept. of Biomedical Imaging and Medicine
University of Malaya Medical Centre, Dept. of Biomedical Imaging and Medicine
University of Malaya Medical Centre, Dept. of Biomedical Imaging and Medicine
University of Malaya Medical Centre, Dept. of Biomedical Imaging and Medicine
University of Malaya Medical Centre, Dept. of Biomedical Imaging and Medicine

Abstract

Background: Leuko-araiosis (LA) and dementia are common geriatric conditions but their pathogenesis and clinical significance are not completely understood. An evaluation of CT perfusion (CTP) in both these conditions can further enhance the understanding of these diseases. Methods: Twenty-one patients with LA and 21 age-matched controls were studied with CTP and assessed for their cognitive function. The subjects were classified into four groups: Group 1, with LA (n = 21); Group 2, without LA (n =21); Group 3, with dementia (n = 7); Group 4, without dementia (n=11). The mean cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT) values were compared between groups 1 and 2, while mean CBF values were compared between groups 3 and 4. Results: Mean white matter CBF was considerably reduced in patients with LA in the frontal region by 42% (p =0.000), basal ganglia by 37% (p = 0.000) and occipital region by 18% (p = 0.019). The mean white matter CBV was reduced in patients with LA in the frontal region by 36% (p = 0.000) and basal ganglia by 28% (p = 0.017). The mean white matter CBF was dramatically reduced in patients with dementia in the frontal region by 44% (p = 0.000), basal ganglia by 32% (p = 0.038) and occipital regions by 24% (p = 0.001). Conclusion: The CTP showed reduced white matter CBF and CBV in patients with LA. This is consistent with chronic ischemia as the pathogenesis of LA. The CTP is also a potentially important technique in the diagnosis and management of dementia, because of its ability to reveal cerebral hypoperfusion.

Item Type:Journal
Keywords:CT Perfusion; Chronic Ischemia; Dementia; Leuko-araiosis
Subjects:R Medicine, Dentistry, Pharmacy, Nursing
ID Code:4496

1. Hachinski , Potter P, Merskey H. Leuko-araiosis. Arch Neurol 1987; 44: 1-23.

2. Pantoni L, Garcia JH. The significance of cerebral white matter abnormalities 100 years after Binswanger’s Report. Stroke 1995; 26: 1293-1301.

3. Silverman DH, Small GW, Kung de Aburto MA, et al. Diagnostic accuracy of FDG-PET in evaluation of dementia: international multi-center pooled brain scan and autopsy data. J Nucl Med 2000; 41:63P.

4. Hoffman JM, Welsh-Bohmer KA, Hanson M et al. FDG PET imaging in patients with pathologically verified dementia. J Nucl Med 2000; 41:1920–1928.

5. Jagust W, Thisted R, Devous MD Sr et al. SPECT perfusion imaging in the diagnosis of Alzheimer’s disease: a clinical–pathologic study. Neurology 2001; 56:950–956.

6. Koenig M, Kraus M, Theek C et al. Quantitative assessment of the ischemic brain by means of perfusion-related parameters derived from perfusion CT. Stroke 2001; 32: 431.

7. Hoeffner EG, Case I, Jain R et al. Cerebral perfusion CT: technique and clinical applications. Radiology 2004; 231: 632-644.

8. Pantoni L, Garcia JH. Pathogenesis of leuko-araiosis. Stroke. 1997; 28: 652–659.

9. Wiszniewska M, Devuyst G, Bogousslavsky J et al. What is the significance of LA in patients with acute ischemic stroke? Stroke 2000; 57:967–973.

10. Liao D, Cooper L, Cai J et al. Presence and severity of cerebral white matter lesions and hypertension, its treatment, and its control. The ARIC Study. Atherosclerosis Risk in Communities Study. Stroke 1996; 27: 2262–2270.

11. Breteler MM, van Swieten JC, Bots ML et al. Cerebral white matter lesions, vascular risk factors and cognitive function in a population-based study: The Rotterdam study. Neurology 1994; 44(7):1246–52.

12. Meyer JS, Rauch GM, Crawford K et al. Risk factors accelerating cerebral degenerative changes, cognitive decline and dementia. Int J Geriatr Psychiatry 1999;14(12):1050–61

13. Tarvonen-Schroder S, Roytta M, Raiha I et al. Clinical features of leukoaraiosis. J Neurol Neurosurg Psychiatry 1996; 60(4):431–6.

14. Kawamura J, Meyer JS, Terayama Y, Weathers S. Leuko-araiosis and cerebral hypoperfusion compared in elderly normal and Alzheimer's dementia. J Am Geriatr Soc 1992; 40:375–80.

15. Markus HS, Lythgoe DJ, Osteogaard L et al. Reduced cerebral blood flow in white matter in ischemic LA demonstarted using quantitative exogenous contrast based perfusion MRI. J Neurology Neurosurgery Psychiatry 2000; 69: 48–53.

16. Starkstein SE, Sabe L, Vasquez S et al. Neuropsychological, psychiatric and cerebral perfusion correlates of LA in Alzheimer’s disease. J Neurology Neurosurgery Psychiatry 1997;63:66–73.

17. Miyazawa N, Satoh T, Hashizume K et al. Xenon contrast CT–CBF measurements in high intensity foci on T2-weighted MR images in centrum semiovale of asymptomatic individuals. Stroke 1997; 28:984–987.

18. Meyer JS, Rogers RL, Judd BW et al. Cognition and cerebral blood flow fluctuate together in multi infarct dementia. Stroke 1988; 19: 63–169.

19. Terayama Y, Meyer JS, Kawamura J et al. Patterns of cerebral hypoperfusion compared among demented and non-demented patients with stroke. Stroke 1992; 23: 686-–92.

20. Talbot PR, Lloyd JJ, Snowden JS et al. A clinical role for 99mTc-HMPAO SPECT in the investigation of dementia. J Nerurology Neurosurgery Psychiatry 1998; 64: 306–313.

21. Charpentier P, Lavenu I, Defebvre L et al. Alzheimer’s disease and frontotemporal dementia are differentiated by discriminant analysis applied to 99mTc-HMPAO SPECT data. J Neurol Neurosurg Psychiatry 2000; 69:661–663.

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