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Using Magnetoencephalography to Investigate Brain Activity during High Frequency Deep Brain Stimulation in a Cluster Headache Patient

Ray, N.J., and Kringelbach, M.L., and Jenkinson, N., and Owen, S.L.F., and Davies, P., and Wang, S.C., and De Pennington, N., and Hansen, P.C., and Stein, J., and Aziz T.Z., (2007) Using Magnetoencephalography to Investigate Brain Activity during High Frequency Deep Brain Stimulation in a Cluster Headache Patient. Biomedical Imaging and Intervention Journal, 3 (1).

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Official URL: http://www.biij.org/2007/1/e25/e25.pdf

Affiliations

University of Oxford, UK. Anatomy and Genetics, Dept. of Physiology
Radcliffe Infirmary, Oxford, UK. Dept. of Neurosurgery
Radcliffe Infirmary, Oxford, UK. Dept. of Neurology

Abstract

Purpose: Treatment-resistant cluster headache can be successfully alleviated with deep brain stimulation (DBS) of the posterior hypothalamus [1]. Magnetoencephalography (MEG) is a non-invasive functional imaging technique with both high temporal and high spatial resolution. However, it is not known whether the inherent electromagnetic (EM) noise produced by high frequency DBS is compatible with MEG.
Materials and methods: We used MEG to record brain activity in an asymptomatic cluster headache patient with a DBS implanted in the right posterior hypothalamus while he made small movements during periods of no stimulation, 7 Hz stimulation and 180 Hz stimulation. Results: We were able to measure brain activity successfully both during low and high frequency stimulation. Analysis of the MEG recordings showed similar activation in motor areas in during the patient’s movements as expected. We also observed similar activations in cortical and subcortical areas that have previously been reported to be associated with pain when the patient’s stimulator was turned on or off [2,3].
Conclusion: These results show that MEG can be used to measure brain activity regardless of the presence of high frequency deep brain stimulation.

Item Type:Journal
Keywords:Magnetoencephalography, DBS, Cluster Headache, Pain
Subjects:R Medicine, Dentistry, Pharmacy, Nursing
ID Code:5067

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2. Fairhurst M, Wiech K, Dunckley P et al. Anticipatory brainstem activity predicts neural processing of pain in humans. Pain 2007; 128(1-2):101-10.

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4. Kringelbach ML, Jenkinson N, Green AL et al. Deep brain stimulation for chronic pain investigated with magnetoencephalography. Neuroreport 2007; 18(3):223-8.

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6. Singh KD, Barnes GR, Hillebrand A et al. Task-related changes in cortical synchronization are spatially coincident with the hemodynamic response. Neuroimage 2002; 16(1):103-14.

7. Baldo BA, Daniel RA, Berridge CW et al. Overlapping distributions of orexin/hypocretin- and dopamine-beta-hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress. J Comp Neurol 2003; 464(2):220-37.

8. Greenberg BD, Malone DA, Friehs GM et al. Three-year outcomes in deep brain stimulation for highly resistant obsessive-compulsive disorder. Neuropsychopharmacology 2006; 31(11):2384-93.

9. Giacobbe P, Kennedy SH. Deep brain stimulation for treatmentresistant depression: a psychiatric perspective. Curr Psychiatry Rep 2006; 8(6):437-44.

10. Zumsteg D, Lozano AM, Wennberg RA. Mesial temporal inhibition in a patient with deep brain stimulation of the anterior thalamus for epilepsy. Epilepsia 2006; 47(11):1958-62.

11. Owen SLF. Connectivity of an effective hypothalamic surgical target for cluster headache. (in preparation).

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