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Analysis of Human Gallstones by FTIR

Channa, Naseem A., and Khand, Fateh D., and Bhanger, Muhammad Iqbal, (2008) Analysis of Human Gallstones by FTIR. Malaysian Journal of Analytical Sciences, 12 (3). pp. 552-560. ISSN 13942506

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Official URL: http://pkukmweb.ukm.my/~mjas/v12_n3/Naseem%20A.pdf

Affiliations

University of Sindh Pakistan, Institute of Biochemistry
Isra University, Pakistan, Dept. of Biochemistry
University of Sindh, Pakistan, National Center of Excellence in Analytical Chemistry

Abstract

The present study was aimed at determining the composition of gallstones removed from patients in Southern Sindh, Pakistan. 109 gallstone samples surgically removed from as many patients (98 females and 11 males; age range 20 to 80 years) admitted for treatment in Liaquat University hospital, Jamshsoro during 2000 to 2003, were analyzed for composition by Fourier Transform Infrared (FTIR) spectroscopy. 74 (67.9%) of the 109 gallstone samples were found to be pure cholesterol stones, 5 (4.6%) pure calcium carbonate stones, 13 (11.9%) cholesterol + calcium carbonate, 10 (9.2%) cholesterol + bilirubin and 07 (6.4%) calcium bilirubinate stones. In mixed composition gallstones cholesterol concentrated more at periphery than in the center of stone. Cholesterol either singly (67.9%) or in combination with either calcium carbonate (11.9%) or bilirubin (9.2%) was the most predominant component of gallstones. Analysis of gallstones based on FTIR suggests that cholesterol either singly or in combination with either calcium carbonate or bilirubin is the most predominant component of gallstones from Southern Sindh, Pakistan.

Item Type:Journal
Keywords:Gallstones, Composition, FTIR, Cholesterol, Bilirubin, Calcium bilirubinate, Calcium carbonate, mixed gallstones.
Subjects:Q Science, Computer Science
ID Code:5166

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