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Spectrophotometric determination of Allopurinol in tablet formulation

Khayoon, Wejdan Shakir, and Al-Abaichy, Mouyad Qassim, and Mohamed Jasim, and Al-Hamadany, Mohamad Affan, (2008) Spectrophotometric determination of Allopurinol in tablet formulation. Journal of Physical Science, 19 (2). pp. 23-30.

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Official URL: http://www.usm.my/jps/19-2-08/Article%2019-2-3.pdf

Affiliations

Universiti Sains Malaysia. School of Chemical Sciences
Baghdad University, Iraq. College of Science. Dept. of Chemistry
Baghdad University, Iraq. College of Science. Dept. of Chemistry
Baghdad University, Iraq. College of Science. Dept. of Chemistry

Abstract

A new spectrophotometric method for the determination of allopurinol drug was investigated. The proposed method was based on the reaction of the intended drug with catechol and Fe(II) to form a blue soluble complex which was measured at λmax 580 nm. A graph of absorbance versus concentration shown that Beer’s law was obeyed over the concentration range of 2–10 μg ml–1 with molar absorptivity of 9.4 x 103 l mol–1 cm–1 and Sandell sensitivity of 1.4 x 10–2 μg cm–2. A recovery percentage of 100% with RSD of 1.0%–1.3% was obtained. The proposed method was applied successfully for the determination of allopurinol drug in tablets with a good accuracy and precision. The optimum condition for the color development has also been investigated.

Item Type:Journal
Keywords:allopurinol, spectrophotometric methods, tablet
Subjects:Q Science, Computer Science
ID Code:5512

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