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Synthesis of hydroxyl radical scavengers from benzalacetone and its derivatives

Sri Handayani, and Indyah Sulistyo Arty, (2008) Synthesis of hydroxyl radical scavengers from benzalacetone and its derivatives. Journal of Physical Science, 19 (2). pp. 61-68.

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Official URL: http://www.usm.my/jps/19-2-08/Article%2019-2-7.pdf

Affiliations

State University of Yogyakarta, Indonesia. Faculty of Mathematics and Natural Sciences. Dept. of Chemical Education
State University of Yogyakarta, Indonesia. Faculty of Mathematics and Natural Sciences. Dept. of Chemical Education

Abstract

Synthesis of hydroxyl radical scavengers from benzalacetone and its derivatives has been done. Benzalacetone synthesis was done by crossed aldol condensation between benzaldehyde and acetone with 1:1 mol ratio, while dibenzalacetone in 2:1 mol ratio. Benzalacetone derivatives were synthesized by replacing benzaldehyde with its derivatives, i.e. p-anisaldehyde, veratraldehyde and cinnamaldehyde. The compounds that were active as radical scavengers based on the IC50 value from the highest level were: dibenzalacetone, veratralacetone, dicinnamalacetone, diveratralacetone and anisalacetone.

Item Type:Journal
Keywords:benzalacetone and its derivatives, IC50, hydroxyl radical scavenger
Subjects:Q Science, Computer Science
ID Code:5518

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