Role of Electron Microscopy in Nipah Virus Outbreak Investigation and Control
Chua, K.B., and Wong, Elsie M.H., and Cropp, Bruce C., and Hyatt, Alex D., (2007) Role of Electron Microscopy in Nipah Virus Outbreak Investigation and Control. Medical Journal of Malaysia, 62 (2). pp. 139-142. ISSN 0300-5283
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National Public Health Laboratory, Malaysia
University of Malaya. Faculty of Medicine
Center for Diseases Control and Prevention, Georgia, USA
Australian Animal Health Laboratory
In 1998, a novel paramyxovirus (order Mononegavirales, family Paramyxoviridae, subfamily Paramyxovirinae, genus Henipavirus) emerged in peninsular Malaysia causing fatal encephalitis in humans and severe respiratory illness with encephalitis in pigs. The virus was successfully isolated in cultured mammalian cells. Transmission electron microscopy of infected tissue culture cells played a crucial role in the early preliminary identification of the causative agent of the outbreak. This in turn was pivotal to determine the correct direction of control measures that subsequently brought the epidemic under control. In light of this investigation, and indeed identification of infectious agents associated with other disease episodes, electron microscopy will remain an important frontline method for rapid diagnostic virology and investigation of any future outbreak of new and unusual cases of illness suspected of an infectious aetiology.
|Additional Information:||We are grateful to Dr Fauziah, Electron Microscopy Unit, University Putra Malaysia, Serdang for her kind permission to use the LEO 972 AB EFTEM electron microscope.|
|Keywords:||Electron microscopy, Nipah virus, Outbreak investigation, infectious diseases, Malaysia|
|Subjects:||R Medicine, Dentistry, Pharmacy, Nursing|
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