Author, Subjects, Keywords

Cited Author

 
 
   » By Author or Editor
 » Browse Author by Alphabet
 » By Journal
 » By Subjects
 » Malaysian Journals
 » By Type
 » By Year
 » By Latest Additions
 
 
   » By Author
 » Top 20 Authors
 » Top 20 Article
 » Top Journal Cited
 » Top Article Cited
 » Journal Citation Statistics
 » Usage Since Sept 2007


 
 
 

Login | Create Account

Antibodies in Systemic Lupus Antineutrophil Cytoplasmic Erythematosus: Prevalence, Disease Activity Correlations and Organ System Associations

Fauzi, A.R., and Kong, N.C.T., and Chua, M.K., and Jeyabalan, N., and Idris, M.N., and Azizah R., (2004) Antibodies in Systemic Lupus Antineutrophil Cytoplasmic Erythematosus: Prevalence, Disease Activity Correlations and Organ System Associations. Medical Journal of Malaysia, 59 (3). pp. 372-377. ISSN 0300-5283

Full text not available from this repository.

Affiliations

Universiti Kebangsaan Malaysia. Dept. of Medicine.
Universiti Kebangsaan Malaysia. Dept. of Medicine
Universiti Kebangsaan Malaysia. Dept. of Medicine
Universiti Kebangsaan Malaysia. Dept. of Medicine
Universiti Kebangsaan Malaysia. Dept. of Medicine
Institute of Medical Research Malaysia

Abstract

Systemic Lupus Erythematosus (SLE) is a disease with multiorgan involvement and multiple autoantibody production including antineutrophil cytoplasmic antibodies (ANCA). Despite its reported prevalence in more thati one third of SLE patients, the role of ANCA in the pathogenesis or otherwise in SLE remains unresolved. 131 SLE patients had been previously studied for various serologic parameters of disease activity. Their cumulative organ involvement in the course of their disease had also been determined and the Lupus Activity Index (LAI) calculated. Their stored sera were then screened for the presence of ANCA by two methods viz Indirect immunofluorescence (IIF) and also enzyme-linked immunosorbent assay (ELISA). ANCA was present in 24.8% of these SLE patients. The atypical ANCA pattern was predominant and accounted for an overall of 20.6%. Anti-MPO and anti-PR3 were detected in 1.5% of patients respectively. No association was found between ANCA positivity and disease activity. There was also no association of ANCA with specific organ involvement. Despite the high prevalence of ANCA especially the atypical variant in SLE, they probably represent only one of the wide repertoire of autoantibodies found in this disease. Routine testing for ANCA in lupus patients is therefore not recommended.

Item Type:Journal
Keywords:SLE, ANCA, Pleuritis, Lupus
Subjects:R Medicine, Dentistry, Pharmacy, Nursing
ID Code:6107

1. Peter AM, Richard PP, Yu CC, Steven JS, John LN. Prevalence of antineutrophil cytoplasmic antibodies in a large inception cohort of patients with connective tissue disease. Ann Int Med 97; 126: 866-73.

2. van der Woude FJ, Rasmussen N, Permin H, van der Giessen M, Wiik A, Lobatto S, et al. Autoantibodies against neutrophils and monocytes : Tool for diagnosis and marker of disease activity in Wegener’s granulomatosis. Lancet 1985; 1: 425.

3. Davenport A, Lock RJ, Wallington TB, Feest TG. Clinical significant of the serial measurement of autoantibodies to neutrophils cytoplasm using a standard indirect immunofluorescence test. Am J Nephrol 1995; 15: 201-7.

4. de Bandt M, Meyer D, Haim T. Antineutrophil cytoplasmic antibodies in rheumatoid arthritis patients. Br J of Rheumatol 1996; 35(1): 38-42.

5. Spronk PR, Bootsma H, Horst G, Huitema MG, Koolen MI. Antineutrophil cyroplasmic antibodies in systemic lupus erythematosus. Br J Rheumatol 1996; 35: 625-31.

6. Nassberger L, Sjoholm AG, Jonsson H, Sturfelt G, Akesson Al. Circulating anti elastase in systemic lupus erythematosus (letter). Lancet 1989; 333: 509.

7. Cambridge G, Wallace H, Bernsteim RH, Leaker B. Autoantibodies to myeloperoxidase in idiopathic and drug induced systemic lupus erythematosus and vasculitis. Br J Rheumatol 1994; 33: 109-14.

8. Pauzner R, Urowitz A, Gladman D, Gough J. Antineutrophil cytoplasmic antibodies in systemic lupus erythematosus. J Rheumatol 1994; 21: 9; 1670-73.

9. Kabasakal Y, Aksu K, Oksel F, Keser G, Ynal V, Kocanaoeullary H et al. Antineutrophil cytoplasmic antibodies in systemic lupus erythematosus: the prevalence and the relation with clinical finding. Arthritis Rheum 1999; 42(9): 0304.

10. Chin HJ, Curie A, SL Chun, Chung HK. Clinical implications of antineutrophil cytoplasmic antibody test in lupus nephritis. Am J Nephrol 2000; 20(1); 57-64.

11. Scnaebel A, Csernok F, Isenberg DA, Mrowks C, Gross WL. Antineutrophil cytoplasmic antibodies in SLE: prevalence, specificities and clinical significance. Arthritis Rheum 1995; 38: 633-7.

12. Falk RJ, Jennette JC. Anti neotrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and cerscentic glomerulonephritis. N Engl J Med 1988; 318: 1651.

13. Kuster S, Apenberg S, Andrassy K, Ritz E. Antineutrophil cytoplasmic antibodies in SLE. Contrib Nephrol 1992: 99; 94-98.

14. Lee SS, Lawton JWM, Chak W. Distinction between antinuclear antibody and pANCA. J Clin Pathol 1991; 44: 962-62.

15. Niles JL, Mc Cluskey RT, Ahmad MF, Arnaout MA. Wegener’s granulomatosis autoantigen is a novel serine proteinases. Blood 1989; 74: 1888-93.

Repository Staff Only: item control page
 
 
 
 
 
 
© Copyright 2007 MyAIS Faculty of Computer Science and Information Technology, University of Malaya – All Rights Reserved. Malaysian Abstracting and Indexing System is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.