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Effects Of An Indigeneous Contraceptive Herbal Formulation On Gonadotrophs Of The Pituitary Gland Of The Rat.

Mohd. Nazrul Islam, and Siti Amrah Sulaiman, and Kapitonova, M.Y. and Syed Mohsin Sahil Jamallulail, (2007) Effects Of An Indigeneous Contraceptive Herbal Formulation On Gonadotrophs Of The Pituitary Gland Of The Rat. Malaysian Journal of Medical Sciences, 14 (1). pp. 23-27. ISSN 1394195X

Full text not available from this repository.

Official URL: http://www.medic.usm.my/publication/mjms/

Affiliations

Universiti Sains Malaysia, School of Medical Sciences, Dept. of Anatomy
Universiti Sains Malaysia, School of Medical Sciences, Dept. of Pharmacology

Abstract

An indigenous contraceptive herbal formulation consisting of a mixture of Lepidagathis longifolia, Palaquium sp and Phyllagathis rotundifolia is being used by the Temuan Aborigins of Malaysia. Although the previous studies demonstrated that this contraceptive herbal formulation causes anovulatory estrous cycle, altered circulating hormone levels and fetal resorption in rats, but the effects of this formulation on the gonadotrphs of the pituitary gland are yet to be evaluated. The present study was designed to observe the morphometric changes of the
gonadotrophs and the plasma concentrations of follicle stimulating hormone and leutinizing hormone. Thirty five Sprague-Dawley adult female rats were randomly divided into 5 groups. Experimental animals were given a combined herbal extract or individual herbal extract at a dose of 540 mg/kg/day subcutaneously for 7 days. Immunostained gonadotrophs were studied by using image analyzer. FSH and
LH serum concentrations were determined using RIA. The FSH and LH concentrations were low in animals that received combined herbal extract (p<0.01). FSH concentration was noted to be significantly low in animals that received P.
rotundifolia (p<0.05). The mean cell area and cell density of gonadotrophs of animals that received combined herbal extract were significantly low compared to control
group (p<0.05). It was concluded that the herbal extracts do suppress the production of gonaotrophins along with the demonstrable suppresive effect on the FSH cells.

Item Type:Journal
Keywords:Pitutary gland; Gonadotrophins; Gonadotrophs; Herbal contraceptive; Temuan, Orang Asli, Women's health.
Subjects:R Medicine
ID Code:639

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