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Augmentation of Angiogenic and Endothelial Associated Gene Expression by EDM50 in Human Chorion-Derived Stem Cells

Mohd Manzor N.F., and Chua, K.H., and Tan, G.C., and Tan, A.E., and Abdul Rahman H., (2008) Augmentation of Angiogenic and Endothelial Associated Gene Expression by EDM50 in Human Chorion-Derived Stem Cells. Medical Journal of Malaysia, 63 (Supplement A). pp. 11-12. ISSN 0300-5283

Full text not available from this repository.

Affiliations

Universiti Kebangsaan Malaysia. UKM Medical Centre. Dept. of Pathology.
Universiti Kebangsaan Malaysia. UKM Medical Centre. Dept. of Physiology.
Universiti Kebangsaan Malaysia. UKM Medical Centre. Dept. of Pathology.
Universiti Kebangsaan Malaysia. UKM Medical Centre. Dept. of Obstetrics & Gynaecology.
Universiti Kebangsaan Malaysia. UKM Medical Centre. Dept. of Pathology.

Abstract

The objective of this study was to investigate the angiogenic potential of human chorion-derived stem cells (CDSC) cultured in medium containing bFGF and VEGF (EDM50). Total RNA was extracted from cells cultured in FD+10%FBS and EDM50. Quantitative RT-PCR was carried out to score the differential mRNA expression of genes involve in angiogenesis and endothelial differentiation. Our finding demonstrated that all angiogenic and endothelial associated genes were expressed higher in EDM50. Expression level of ANG-1, eNOS and VEGFR2 were significantly higher in EDM50 compared to FD+10%FBS. Our results suggested that human CDSC cultured in EDM50 can be used for angiogenesis purpose in regenerative medicine.

Item Type:Journal
Additional Information:In conclusion, our report suggested that human chorionderived stem cells cultured in EDM50 can be used for angiogenesis purpose in regenerative medicine.
Subjects:R Medicine, Dentistry, Pharmacy, Nursing
ID Code:6484

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