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Current Progress and Challenges in Ocular Surface Reconstruction Using Cultivated Epithelial Sheet Transplantation

Inatomi, T. , and Nakamura, T. , and Koizumi, N. , and Sotozono, C. , and Kinoshita, S., (2008) Current Progress and Challenges in Ocular Surface Reconstruction Using Cultivated Epithelial Sheet Transplantation. Medical Journal of Malaysia, 63 (Supplement A). 42. ISSN 0300-5283

Full text not available from this repository.

Affiliations

Kyoto Prefectural University of Medicine, Japan. Dept. of Ophthalmology.
Kyoto Prefectural University of Medicine, Japan. Dept. of Ophthalmology.
Kyoto Prefectural University of Medicine, Japan. Dept. of Ophthalmology.
Kyoto Prefectural University of Medicine, Japan. Dept. of Ophthalmology.
Kyoto Prefectural University of Medicine, Japan. Dept. of Ophthalmology.

Abstract

The cultivated epithelial transplantation is a new surgical modality for treating a variety of severe ocular surface disorders. This type of tissue-engineered epithelial sheet provides a rapid epithelial coverage on the corneal surface that reduces inflammation and postoperative complications. Although cultivated corneal epithelial transplantation is an effective surgical strategy, autologous transplantation is limited to unilateral cases. Autologous cultivated oral mucosal epithelial transplantation (COMET) enables surgeons to reconstruct the ocular surface using autologous, non-ocular surface cells, and has opened a new pathway for treating severe, bilateral ocular surface disorders.

Item Type:Journal
Additional Information:We successfully established a procedure for generating a transplantable, tissue-engineered, oral-mucosal epithelial sheet. The ocular surface was reconstructed using this non-ocular originated epithelium without it returning to an in vivo oral tissue phenotype. The clinical application of autologous, oral mucosal epithelial transplantation reduces inflammation and postoperative complications, which has proven to be useful as an alternative treatment for ocular surface diseases.
Keywords:Skin tissue engineering, epithelial transplantation
Subjects:R Medicine, Dentistry, Pharmacy, Nursing
ID Code:6615

1. Koizumi N, Inatomi T, Quantock AJ, et al. Amniotic membrane as a substrate for cultivating limbal corneal epithelial cells for autologous transplantation in rabbits. Cornea. 2000; 19(1): 65-71.

2. Koizumi N, Inatomi T, Suzuki T, et al. Cultivated corneal epithelial transplantation for ocular surface reconstruction in acute phase of Stevens-Johnson syndrome. Arch. Ophthalmol. 2001; 19(2): 298-300.

3. Koizumi N, Inatomi T, Suzuki T, et al. Cultivated corneal epithelial stem cell transplantation in ocular surface disorders. Ophthalmology. 2001; 108(9): 1569—74.

4. Nakamura T, Inatomi T, Sotozono C, et al. Transplantation of cultivated autologous oral mucosal epithelial cells in patients with severe ocular surface disorders. Br. J. Ophthalmol. 2004; 88: 1280-4.

5. Inatomi T, Nakamura T, Koizumi N, et al. Current concepts and challenges in ocular surface reconstruction using cultivated mucosal epithelial transplantation. Cornea. 2005; 24(suppl): S32-S38.

6. Inatomi T, Nakamura T, Koizumi N, et al. Midterm results of cultivated oral mucosal epithelial transplantation. Am.J. Ophthalmol. 2006; 141: 267-75.

7. Inatomi T, Nakamura T, Kojyo M, et al. Ocular surface reconstruction with combination of cultivated oral mucosal epithelial transplantation and penetrating keratoplasty. Am. J. Ophthalmol. 2006; 142: 757-64.

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