Effects Of Andrographis Paniculata Extract On Uridine Diphosphate Glucuronosyltransferase Activity
Norzainah Ahmad, and Sabariah Ismail, and Abas Hj. Hussin, (2005) Effects Of Andrographis Paniculata Extract On Uridine Diphosphate Glucuronosyltransferase Activity. Malaysian Journal of Pharmaceutical Sciences, 3 (1). pp. 25-33. ISSN 1675-7319
Official URL: http://www.pha.usm.my/pharmacy/Webpage%20journal/abstract/3.1-3.pdf
Universiti Sains Malaysia, Advanced Medical and Dental Institute
Universiti Sains Malaysia, Centre for Drug Research.
Universiti Sains Malaysia, School of Pharmaceutical Sciences.
The effects of the ethanolic extract of the aerial parts of Andrographis paniculata (AP) on glucuronidation reaction in rat liver microsomes were examined under both in vivo and in vitro conditions. In vitro, AP ethanolic extract at 5 pg/mg protein significantly increased p-nitrophenol (p-NP) uridine diphosphate glucuronosyltransferase (UGT) activity whilst AP at 50 ug/mg protein had no effect on p-NP UGT activity. However, AP ethanolic extract at 500 pg/mg protein significantly decreased p-NP UGT activity. In vivo, administration of single doses of AP ethanolic extract (75 mg/kg/day, p.o.) to adult male Sprague-Dawley rats (n = 7, 140 ± 22 g, body weight) for 15 consecutive days significantly decreased p-NP UGT activity (treated: 1.97 ± 0.15 nmol/min/mg versus control: 2.50 ± 0.15 nmol/min/mg protein). There were no significant changes
in body or liver weights of the rats.
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