Preparation Of Antituberculosis Dry Powder Inhalers Using Physical Mixing And Spray Drying

Sawatdee, Somchai, and Srichana, Teerapol, and Worakul, Nimit, (2004) Preparation Of Antituberculosis Dry Powder Inhalers Using Physical Mixing And Spray Drying. Malaysian Journal of Pharmaceutical Sciences, 2 (2). pp. 26-26. ISSN 16575-7319

Abstract

BACKGROUND: Tuberculosis is the most significant infection causing human diseases. The current treatment of pulmonary tuberculosis involved prolonged oral administration of high dose of combined antibiotics, which is associated with unwanted side effects and poor compliances. Direct lung delivery of antituberculosis drugs may be able to solve these problems.

OBJECTIVES: To study and develop antituberculosis drugs as dry powder inhaler in order to deliver to the lower airways in vitro.

MATERIALS AND METHODS: Rifampicin and isoniazid as micronized particles were used to formulate dry powder
inhalers by physical mixing with various ratios of fine and micronized trehalose, mannose or lactose as carriers. Isoniazid was prepared by spray drying technique using trehalose and lactose as carriers. All of the formulations were evaluated for the content uniformity of dosage, fine
particle fraction (FPF) which particle size less than 6.4 p.m that obtained by twin stage impinger, and mass median aerodynamic diameter (MMAD) that obtained by Andersen cascade impactor.

RESULT: All of physical mixing and spray drying formulations have high content uniformity (99.56± 2.49%). FPF and MMAD of selected formulations are as follow:

CONCLUSION: These formulations indicate that suitable particle size for lung delivery of antituberculosis drugs were obtained.

Preparation Of Antituberculosis Dry Powder Inhalers Using Physical Mixing And Spray Drying

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Abstract