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Study Of Interaction Of Drugs With Body-Alike Macromolecule (Polyvinylpyrrolidone)By Ultra Violet Spectroscopic Method

Saeed, Akhtar, and Ur Rahman, Amin, and Ul Islam, Nazar, and Saeed, Mohammad, and Ashhad, Halimi, Syed Mohammad, (2006) Study Of Interaction Of Drugs With Body-Alike Macromolecule (Polyvinylpyrrolidone)By Ultra Violet Spectroscopic Method. Malaysian Journal of Pharmaceutical Sciences, 4 (2). pp. 63-73. ISSN 16575-7319

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Official URL: http://www.pha.usm.my/pharmacy/Webpage%20journal/abstract/4.2-6.pdf

Affiliations

University of Peshawar, Pakistan, National Center of Excellence in Physical Chemistry
University of Peshawar, Pakistan, National Center of Excellence in Physical Chemistry, Pakistan.
University of Peshawar, Pakistan, Dept. of Pharmacy.
International Islamic University Malaysia. Kulliyyah of Pharmacy, Dept. of Pharmaceutical Chemistry.
L. R. Hospital, Government Medicines Co-ordination Cell, Pakistan.

Abstract

UV-visible spectrophotometric technique was used to study the interaction of polyvinylpyrrolidone (PVP) with co-solutes: phenol, benzoic acid, sodium benzoate, salicylic acid and acetyl salicylic acid in aqueous medium. Changes in the absorption spectra of the co-solutes were observed in the presence of PVP from 200 to 210 inn. The changes were attributed to interaction of PVP molecules with the co-solute molecules. As the concentration of the co-solute increased, a red shift in the bands was observed indicating an increase in interaction between PVP and the co-solute.

Item Type:Journal
Keywords:Polyvinylpyrrolidone, Phenol, Benzoic acid, Acetyl salicylic acid, UV-visible spectrometry
Subjects:R Medicine, Dentistry, Pharmacy, Nursing
ID Code:7038

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