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Treatment of Chronic Hepatitis C Virus Infection with Interferon Alfa and Ribavirin: Sustained Response in Two Patients with Transfusion Dependent Thalassaemia

Hamidah A., and Yong, J.F., and Zulkifli H.I., and Jamal R., (2002) Treatment of Chronic Hepatitis C Virus Infection with Interferon Alfa and Ribavirin: Sustained Response in Two Patients with Transfusion Dependent Thalassaemia. Medical Journal of Malaysia, 57 (3). pp. 353-356. ISSN 0300-5283

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Affiliations

Universiti Kebangsaan Malaysia. Faculty of Medicine. Dept. of Paediatrics.
Universiti Kebangsaan Malaysia. Faculty of Medicine. Dept. of Paediatrics.
Universiti Kebangsaan Malaysia. Faculty of Medicine. Dept. of Paediatrics.
Universiti Kebangsaan Malaysia. Faculty of Medicine. Dept. of Paediatrics.

Abstract

We describe two cases of transfusion dependent thalassaemics with chronic hepatitis C virus infection whom were treated successfully with interferon and ribavirin, following failure of response or relapse after an initial response to interferon monotherapy. They had sustained virological response for more than twelve months after completing therapy. Transfusion requirements were significantly increased during the combination therapy, probably due to ribavirin-induced haemolysis. Serum ferritin level decreased significantly during the treatment. Combination therapy with interferon alfa and ribavirin may be a feasible treatment option for some nonresponders to prior interferon monotherapy.

Item Type:Journal
Keywords:Thalassaemia, Blood transfusion, Hepatitis C virus, Interferon, Ribavirin
Subjects:R Medicine, Dentistry, Pharmacy, Nursing
ID Code:7235

1. Jamal R, Fadzillah G, Zulkifli SZ, Yasmin M. Seroprevalence of Hepatitis B, Hepatitis C, CMV and HIV in multiply transfused thalassemia patients: Results from a thalassemia day care center in Malaysia. Southeast Asian J Trop Public Health. December 1998; 29: 792-94.

2. Guidelines for the Clinical Management of Thalassaemia. Published by Thalassaemia International Federation. April 2000; 50-55.

3. Telfer PT, Garson JA, Whitby K et al. Combination therapy with interferon alpha and ribavirin for chronic hepatitis C virus infection in thalassaemic patients. British Journal of Haematology. June 1997; 98: 850-55.

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