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Time Delay and its Effect on Survival in Malaysian Patients with Non-Small Cell Lung Carcinoma

Loh, Li Cher and Chan, Li Yen and Tan, Ru Yu and Govindaraju, Selvaratnam and Ratnavelu, Kananathan and Kumar, Shalini and Raman, Sree and Vijayasingham, Pillai and Thayaparan, Tamizi (2006) Time Delay and its Effect on Survival in Malaysian Patients with Non-Small Cell Lung Carcinoma. Malaysian Journal of Medical Sciences, 13 (1). pp. 37-42. ISSN 1394195X

Full text not available from this repository.

Official URL: http://www.medic.usm.my/publication/mjms/

Affiliations

International Medical University Negeri Sembilan, Clinical School, Lung Research Unit,
Seremban Hospital Malaysia, Dept. of Pathology
Seremban Hospital Malaysia, Dept. of Medicine

Abstract

While evidence indicates that early stage disease has better prognosis, the effect of delay in presentation and treatment of patients with non-small cell lung cancer(NSCLC) on survival is debatable. A retrospective study of 122 Malaysian patients with NSCLC was performed to examine the presentation and treatment delay, and its relation with patient survival. Median (25-75% IQR) interval between onset of symptoms and first hospital consultation (patient delay) and between first hospital consultation and treatment or decision to treat (doctor delay) were 2 (1.0-5.0) and 1.1 (0.6-2.4) months respectively. The median survival rates in patient delay of <1, 1 to 3, and >3 months were 4.1 (9.9-1.7), 5.1 (10.9-3.2) and 5.7 (12.3-
2.1) months respectively (log rank p=0.648), while in doctor delay, <30, 30-60, >60 days, the rates were 4.1 (10.8-1.8), 7.6 (13.7-3.2) and 5.3 (16.0-3.0) months
respectively (p=0.557). Most patients presented and were treated in a relatively short time, and delays did not appear to influence survival. This Asian data is consistent with those from Western population, reiterating the need for public health measures that can identify disease early.

Item Type:Journal
Keywords:Non-small cell lung cancer, Malaysia, survival, time delay
Subjects:R Medicine
ID Code:830

1. Janssen-Heijnen M.L, Gatta G, Forman D, Capocaccia R, Coebergh J.W. Variation in survival of patients with lung cancer in Europe, 1985-1989. Eur J Cancer 1998;

34: 2191-2196.

2. Deslauriers J. Current surgical treatment of nonsmall cell lung cancer 2001. Eur Respir J Suppl 2002; 35: 61s-70s.

3. Falk SJ, Girling D.J, White R.J, et al. Immediate versus delayed palliative thoracic radiotherapy in patients with unresectable locally advanced non-small cell lung cancer and minimal thoracic symptoms: randomized controlled trial. BMJ 2002; 325: 465.

4. Christensen ED, Harvald T, Jendresen M, Aggestrup S, Petterson G. The impact of delayed diagnosis of lung cancer on the stage at the time of operation. Eur J

Cardiothorac Surg 1997; 12: 880-4.

5. Jensen A.R, Mainz J, Overgaard J. Impact of delay on diagnosis and treatment of primary lung cancer. Acta Oncol 2002; 41: 147-52.

6. Bozcuk H, Martin C. Does treatment delay affect survival in non-small cell lung cancer? A retrospective analysis from a single UK centre. Lung Cancer 2001;

34: 243-52.

7. Koyi H, Hillerdal G, Branden E. Patient’s and doctors’ delays in the diagnosis of chest tumors. Lung Cancer 2002; 35: 53-7.

8. Lim G.C.C, Yahaya H, Lim T.O. The first report of the national cancer registry cancer incidence in Malaysia 2002. National Cancer Registry, Ministry of Health Malaysia 2002.

9. Bray F, Sankila R, Ferlay J, Parkin DM. Estimates of cancer incidence and mortality in Europe in 1995. Eur J Cancer 2002; 38: 99-166.

10. Billing J.S, Wells F.C. Delays in the diagnosis and surgical treatment of lung cancer. Thorax 1996; 51:903-6.

11. Myrdal G, Lambe M, Hillerdal G, Lamberg K, Agustsson T, Stahle E. Effect of delays on prognosis in patients with non-small cell lung cancer. Thorax 2004; 59: 45-9.

12. Jones R.V, Dudgeon T.A. Time between presentation and treatment of six common cancers: a study in Devon. Br J Gen Pract 1992; 42: 419-22.

13. Simunovic M, Gagliardi A, McCready D, Coates A, Levine M, DePetrillo D. A snapshot of waiting times for cancer surgery provided by surgeons affiliated with

regional cancer centres in Ontario. CMAJ 2001; 165: 421-5.

14. O’Rourke N, Edwards R. Lung cancer treatment waiting times and tumour growth. Clin Oncol (R Coll Radiol) 2000; 12: 141-4.

15. Aragoneses F.G, Moreno N, Leon P, Fontan E.G, Folque E. Influence of delays on survival in the surgical treatment of bronchogenic carcinoma. Lung Cancer 2002; 36: 59-63.

16. Geddes D.M. The natural history of lung cancer: a review based on rates of tumour growth. Br J Dis Chest 1979; 73: 1-17.

17. Northern and Yorkshire Cancer Registry and Information Service (NYCRIS). A report on incidence and management for the main sites of cancer 1999. Leeds: NYCRIS 2002; 1-56.

18. Siegfried J.M. Lung cancer screening in high-risk populations. Clin Lung Cancer 1999; 1: 100-6.

19. Warner E.E. & Mulshine J.L. Lung cancer screening with spiral CT: toward a working strategy. Oncology (Huntingt) 2004; 18: 564-75.

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