Author, Subjects, Keywords

Cited Author

 
 
   » By Author or Editor
 » Browse Author by Alphabet
 » By Journal
 » By Subjects
 » By Affiliations
 » By Type
 » By Year
 » By Latest Additions
 
 
   » By Author
 » Top 20 Authors
 » Top 20 Article
 » Top 20 Journal Cited
 » Top 20 Cited
 » Top 20 Author Cited
 » Usage Since Sept 2007


 
 
 

Login | Create Account

The Role of the Thalamus in Modulating Pain

Che Badariah Ab Aziz, and Asma Hayati Ahmad, (2006) The Role of the Thalamus in Modulating Pain. Malaysian Journal of Medical Sciences, 13 (2). pp. 11-18. ISSN 1394195X

Full text not available from this repository.

Official URL: http://www.medic.usm.my/publication/mjms/

Affiliations

Universiti Sains Malaysia, School of Medical Sciences, Dept. of Physiology

Abstract

The thalamus is one of the structures that receives projections from multiple ascending pain pathways. The structure is not merely a relay centre but is involved in processing nociceptive information before transmitting the information to various parts of the cortex. The thalamic nuclei are involved in the sensory discriminative and affective motivational components of pain. Generally each group of nucleus has prominent functions in one component for example ventrobasal complex in sensory discriminative component and intralaminar nuclei in affectivemotivational
component. The thalamus is also part of a network that projects to the spinal cord dorsal horn and modulates ascending nociceptive information. In the animal models of neuropathic pain, changes in the biochemistry, gene expression, thalamic blood flow and response properties of thalamic neurons have been shown. These studies suggest the important contribution of the thalamus in modulating pain in normal and neuropathic pain condition.

Item Type:Journal
Keywords:Thalamus, pain, electrophysiology, imaging
Subjects:R Medicine
ID Code:840

1. Cross S.A. Pathophysiology of Pain. Mayo Clin Proc. 1994; 69:375– 83.

2. Woolf C.J. Pain. Neurobiol Dis. 2000; 7: 504-10.

3. Windhorst U. Sensory Systems and Functions: Central Projections of Cutaneous and Enteroceptive Senses. In Greger, R and Windhorst, U eds. Comprehensive Human Physiology. From Cellular Mechanisms to Integration. Vol 1. Berlin: Springer, 1996:623-46.

4. Millan M.J. Descending control of pain. Prog Neurobiol. 2002; 66:355-474.

5. Melzack R. Pain-an overview. Acta Anaesthesiol Scand1999; 43(9):880-84.

6. Andersson J.L., Lilja A, Hartvig P, Langstrom B, Gordh

T, Handwerker H, et al. Somatotopic organization along the central sulcus, for pain localization in humans, as revealed by positron emission tomography. Exp Brain Res 1997; 117(2): 192-99.

7. Craig A.D. A new view of pain as a homeostatic emotion. Trends Neurosci 2003; 26(6) : 303-07.

8. Valet M, Sprenger T, Boecker H, Willoch F, Rummeny E, Conrad B, et al. Distraction modulates connectivity of the cingulo-frontal cortex and the midbrain during pain—an fMRI analysis. Pain 2004; 109(3): 399-408.

9. Abdul Aziz A.A., Finn D.P., Mason R, Chapman V. Comparison of responses of ventral posterolateral and posterior complex thalamic neurons in naive rats and rats with hindpaw inflammation: mu-opioid receptor mediated inhibitions. Neuropharmacology 2005; 48(4):607-16.

10. Hsieh J.C, Belfrage M, Stone-Elander S, Hansson P, Ingvar M. Central representation of chronic ongoing neuropathic pain studied by positron emission tomography. Pain 1995; 63(2): 225-36.

11. Lorenz J, Cross D, Minoshima S, Morrow T, Paulson P, Casey K. A unique representation of heat allodynia in the human brain. Neuron 2002; 35(2): 383-93.

12. Porro C.A, Lui F, Facchin P, Maieron M, Baraldi P. Percept-related activity in the human somatosensory system: functional magnetic resonance imaging studies. Magn Reson Imaging 2004; 22(10): 1539-548.

13. Zhuo M, Gebhart G.F. Characterization of descending inhibition and facilitation from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat. Pain 1990; 42(3): 337-50.

14. Apkarian A.V., Hodge C.J. Primate spinothalamic pathways: III. Thalamic terminations of the dorsolateral and ventral spinothalamic pathways. J Comp Neurol 1989; 288(3):493-511.

15. Dado R.J, Katter J.T, Giesler G.J, Jr. Spinothalamic and spinohypothalamic tract neurons in the cervical enlargement of rats. I. Locations of antidromically identified axons in the thalamus and hypothalamus. J Neurophysiol 1994; 71(3): 959-80.

16. Katter J.T, Dado R.J, Kostarczyk E, Giesler G.J, Jr. Spinothalamic and spinohypothalamic tract neurons in the sacral spinal cord of rats. I. Locations of antidromically identified axons in the cervical cord and diencephalon. J Neurophysiol 1996; 75(6): 2581-605.

17. Kenshalo D.R, Jr., Isensee O. Responses of primate SI

cortical neurons to noxious stimuli. J Neurophysiol 1983; 50(6): 1479-496.

18. Royce G.J, Mourey R.J. Efferent connections of the centromedian and parafascicular thalamic nuclei: an autoradiographic investigation in the cat. J Comp Neurol 1985; 235(3): 277-300.

19. Desbois C, Villanueva L. The organization of lateral

ventromedial thalamic connections in the rat: a link for the distribution of nociceptive signals to widespread cortical regions. Neuroscience 2001; 102(4): 885-98.

20. Shyu B.C, Lin C.Y, Sun J.J, Chen S.L, Chang C. Bold response to direct thalamic stimulation reveals a functional connection between the medial thalamus and the anterior cingulate cortex in the rat. Magn Reson Med 2004; 52(1): 47-55.

21. Bester H, Bourgeais L, Villanueva L, Besson J.M, Bernard J.F. Differential projections to the intralaminar and gustatory thalamus from the parabrachial area: a PHA-L study in the rat. J Comp Neurol 1999; 405(4):421-49.

22. Bourgeais L, Monconduit L, Villanueva L, Bernard J.F. Parabrachial internal lateral neurons convey nociceptive messages from the deep laminas of the dorsal horn to the intralaminar thalamus. J Neurosci 2001; 21(6): 2159-165.

23. Berendse H.W., Groenewegen H.J. Restricted cortical termination fields of the midline and intralaminar thalamic nuclei in the rat. Neuroscience 1991; 42(1): 73-102.

24. Dalley J.W, Cardinal R.N, Robbins T.W. Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates. Neurosci Biobehav Rev 2004; 28(7): 771-84.

25. Blair R.J. The roles of orbital frontal cortex in the modulation of antisocial behavior. Brain Cogn 2004; 55(1): 198-208.

26. Morgan M.A, LeDoux J.E. Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats. Behav Neurosci 1995; 109(4): 681-88.

27. Chaouch A, Menetrey D, Binder D, Besson J.M. Neurons at the origin of the medial component of the bulbopontine spinoreticular tract in the rat: an anatomical study using horseradish peroxidase retrograde transport. J Comp Neurol 1983; 214(3): 309-20.

28. Menetrey D, Roudier F, Besson J.M. Spinal neurons reaching the lateral reticular nucleus as studied in the rat by retrograde transport of horseradish peroxidase. J Comp Neurol 1983; 220(4): 439-52.

29. Vanderhorst V.G, Mouton L.J, Blok B.F, Holstege G. Distinct cell groups in the lumbosacral cord of the cat project to different areas in the periaqueductal gray. JComp Neurol 1996; 376(3): 361-85.

30. Carstens E, Trevino D.L. Laminar origins of spinothalamic projections in the cat as determined by the retrograde transport of horseradish peroxidase. J Comp Neurol 1978; 182(1): 161-65.

31. Sewards T.V, Sewards M.A. Representations of motivational drives in mesial cortex, medial thalamus, hypothalamus and midbrain. Brain Res Bull 2003;61(1): 25-49.

32. Guilbaud G, Peschanski M, Gautron M, Binder D. Neurones responding to noxious stimulation in VB complex and caudal adjacent regions in the thalamusof the rat. Pain 1980; 8(3): 303-18.

33. Berkley K.J, Guilbaud G, Benoist .M, Gautron M. Responses of neurons in and near the thalamic ventrobasal complex of the rat to stimulation of uterus, cervix, vagina, colon, and skin. J Neurophysiol 1993;69(2): 557-68.

34. Bester H, Bourgeais L, Villanueva L, Besson J.M, Bernard J.F. Differential projections to the intralaminar and gustatory thalamus from the parabrachial area: a PHA-L study in the rat. J Comp Neurol 1999; 405(4):421-49.

35. Peschanski M, Guilbaud G, Gautron M. Posterior intralaminar region in rat: neuronal responses to noxious and nonnoxious cutaneous stimuli. Exp Neurol 1981; 72(1): 226-38.

36. Miletic V, Coffield J.A. Responses of neurons in the rat nucleus submedius to noxious and innocuous mechanical cutaneous stimulation. Somatosens Mot Res 1989; 6(5-6): 567-87.

37. Apkarian A.V, Shi T. Squirrel monkey lateral thalamus.I. Somatic nociresponsive neurons and their relation to spinothalamic terminals. J Neurosci 1994; 1411 Pt 2): 6779-795.

38. Monconduit L, Bourgeais L, Bernard J.F, Villanueva L. Convergence of cutaneous, muscular and visceral noxious inputs onto ventromedial thalamic neurons in the rat. Pain 2003; 103(1-2): 83-91.

39. Yen C.T, Shaw F.Z. Reticular thalamic responses to nociceptive inputs in anesthetized rats. Brain Res 2003; 968(2): 179-91.

40. Alitto H.J, Usrey W.M. Corticothalamic feedback and sensory processing. Curr Opin Neurobiol 2003; 13(4):440-45.

41. Peschanski M, Guilbaud G, Gautron M, Besson J.M. Encoding of noxious heat messages in neurons of the ventrobasal thalamic complex of the rat. Brain Res 1980; 197(2): 401-13.

42. Monconduit L, Bourgeais L, Bernard J.F, Le Bars D, Villanueva L. Ventromedial thalamic neurons convey nociceptive signals from the whole body surface to the dorsolateral neocortex. J Neurosci 1999; 19(20):9063-072.

43. Friedman D.P, Murray E.A. Thalamic connectivity of the second somatosensory area and neighboring somatosensory fields of the lateral sulcus of the macaque. J Comp Neurol 1986; 252(3): 348-73.

44. Shigenaga Y, Inoki R. Effect of morphine on single unit responses in ventrobasal complex (VB) and posterior nuclear group (PO) following tooth pulp stimulation. Brain Res 1976; 103(1): 152-56.

45. Poggio G.F, Mountcastle V.B. A study of the functional contributions of the lemniscal and spinothalamic systems to somatic sensibility. Central nervous mechanisms in pain. Bull Johns Hopkins Hosp 1960; 106: 266-316.

46. Craig A.D, Dostrovsky J.O. Medulla to thalamus. In textbook of pain (ed. Wall PD and Melzack R), pp 183-214. Churchill-Livingstone, New York.

47. Curry M.J. The exteroceptive properties of neurones in the somatic part of the posterior group (PO). Brain Res 1972; 44(2): 439-62.

48. Nyquist J.K, Greenhoot J.H. Unit analysis of nonspecific thalamic responses to high-intensity cutaneous input in the cat. Exp Neurol 1974; 42(3): 609-22.

49. Guilbaud G, Kayser V, Benoist J.M, Gautron M. Modifications in the responsiveness of rat ventrobasal thalamic neurons at different stages of carrageeninproduced inflammation. Brain Res 1986; 385(1): 86-98.

50. Guilbaud G, Neil A, Benoist J.M, Kayser V, Gautron M. Thresholds and encoding of neuronal responses to mechanical stimuli in the ventro-basal thalamus during carrageenin-induced hyperalgesic inflammation in the rat. Exp Brain Res 1987; 68(2): 311-18.

51. Guilbaud G, Benoist J.M, Jazat F, Gautron M. Neuronal

responsiveness in the ventrobasal thalamic complex of rats with an experimental peripheral mononeuropathy. J Neurophysiol 1990; 64(5): 1537-554.

52. Kelly S, Jhaveri M.D, Sagar D.R, Kendall D.A, Chapman V. Activation of peripheral cannabinoid CB1 receptors inhibits mechanically evoked responses of spinal neurons in noninflamed rats and rats with hindpaw inflammation. Eur J Neurosci 2003; 18(8): 2239-243.

53. Chapman V, Suzuki R, Dickenson A.H. Electrophysiological characterization of spinal neuronal response properties in anaesthetized rats after ligation of spinal nerves L5-L6. J Physiol 1998; 507 (Pt 3): 881-94.

54. Suzuki R, Chapman V, Dickenson A.H. The effectiveness of spinal and systemic morphine on rat dorsal horn neuronal responses in the spinal nerve ligation model of neuropathic pain. Pain 1999; 80(1-2): 215-28.

55. Coffield J.A, Bowen K.K, Miletic V. Retrograde tracing of projections between the nucleus submedius, the ventrolateral orbital cortex, and the midbrain in the rat. J Comp Neurol 1992; 321(3): 488-99.

56. Craig A.D, Jr., Wiegand S.J, Price J.L. The halamocortical projection of the nucleus submedius in the cat. J Comp Neurol 1982; 206(1): 28-48.

57. Ma W, Peschanski M, Besson J.M. The overlap of spinothalamic and dorsal column nuclei projections in the ventrobasal complex of the rat thalamus: a double anterograde labeling study using light microscopy analysis. J Comp Neurol 1986; 245(4): 531-40.

58. Basbaum A.I, Fields H.L. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci 1984; 7: 309-38.

59. Sandkuhler J, Gebhart G.F. Relative contributions of the nucleus raphe magnus and adjacent medullary reticular formation to the inhibition by stimulation in the periaqueductal gray of a spinal nociceptive reflex in the pentobarbital-anesthetized rat. Brain Res 1984;305(1):77-87.

60. Kawakita K, Dostrovsky J.O, Tang J.S, Chiang C.Y. Responses of neurons in the rat thalamic nucleus submedius to cutaneous, muscle and visceral nociceptive stimuli. Pain 1993; 55(3): 327-38.

61. Fu J.J, Tang J.S, Yuan B, Jia H. Response of neurons in the thalamic nucleus submedius (Sm) to noxious stimulation and electrophysiological identification of on- and off-cells in rats. Pain 2002; 99(1-2): 243-51.

62. Kawakita K, Sumiya E, Murase K, Okada K. Response characteristics of nucleus submedius neurons to colorectal distension in the rat. Neurosci Res 1997; 28(1):59-66.

63. Yang S.W, Follett K.A, Piper J.G, Ness T.J. The effect of morphine on responses of mediodorsal thalamic nuclei and nucleus submedius neurons to colorectal distension in the rat. Brain Res 1998; 779(1-2): 41-52.

64. Fields H.L., Heinricher M.M., Mason P. Neurotransmitters in nociceptive modulatory circuits. Annu Rev Neurosci 1991; 14: 219-45.

65. Heinricher M.M, Morgan M.M, Fields H.L. Direct and indirect actions of morphine on medullary neurons that modulate nociception. Neuroscience 1992; 48(3): 533-43.

66. Heinricher M.M, Cheng Z.F, Fields H.L. Evidence for two classes of nociceptive modulating neurons in the periaqueductal gray. J Neurosci 1987; 7(1): 271-78.

67. Jia H, Xie Y.F, Xiao D.Q, Tang J.S. Involvement of GABAergic modulation of the nucleus submedius (Sm) morphine-induced antinociception. Pain 2004; 108(1-2):28-35.

68. Yang S, Follett K.A. Electrical stimulation of thalamic

Nucleus Submedius inhibits responses of spinal dorsal horn neurons to colorectal distension in the rat. Brain Res Bull 2003; 59(6): 413-20.

69. Zhang Y.Q, Tang J.S, Yuan B, Jia H. Inhibitory effects of electrical stimulation of thalamic nucleus submedius area on the rat tail flick reflex. Brain Res 1995; 696(1-2) 205-12.

70. Erdos B, Lacza Z, Toth I.E, Szelke E, Mersich T, Komjati K, et al. Mechanisms of pain-induced local cerebral blood flow changes in the rat sensory cortex and thalamus. Brain Res 2003; 960(1-2): 219-27.

71. Baron R, Baron Y, Disbrow E, Roberts TP. Brain processing of capsaicin-induced secondary hyperalgesia: a functional MRI study. Neurology 1999; 53(3): 548-57.

72. Casey K.L., Lorenz J, Minoshima S. Insights into the pathophysiology of neuropathic pain through functional brain imaging. Exp Neurol 2003; 184 Suppl 1: S80-8.

73. Paulson P.E, Morrow T.J, Casey K.L. Bilateral behavioral and regional cerebral blood flow changes during painful peripheral mononeuropathy in the rat.Pain 2000; 84(2-3): 233-45.

74. Paulson P.E, Casey K.L., Morrow T.J. Long-term changes in behavior and regional cerebral blood flow associated with painful peripheral mononeuropathy in the rat. Pain 2002; 95(1-2): 31-40.

75. Witting N, Kupers R.C, Svensson P, Arendt-Nielsen L, Gjedde A, Jensen TS. Experimental brush-evoked allodynia activates posterior parietal cortex. Neurology 2001; 57(10): 1817-824.

76. Chang C, Shyu B.C. A fMRI study of brain activations during non-noxious and noxious electrical stimulation of the sciatic nerve of rats. Brain Res 2001; 897(1-2): 71-81.

77. Casey K.L. Forebrain mechanisms of nociception and pain: analysis through imaging. Proc Natl Acad Sci U S A 1999; 96(14): 7668-674.

78. Casey K.L, Minoshima S, Berger K.L, Koeppe RA, Morrow TJ, Frey KA. Positron emission tomographic analysis of cerebral structures activated specifically by repetitive noxious heat stimuli. J Neurophysiol 1994;71(2): 802-07.

79. Coghill R.C, Talbot J.D, Evans A.C, Meyer E, Gjedde A, Bushnell M.C, et al. Distributed processing of pain and vibration by the human brain. J Neurosci 1994; 14(7): 4095-108.

80. Derbyshire S.W, Jones A.K. Cerebral responses to a continual tonic pain stimulus measured using positron emission tomography. Pain 1998; 76(1-2): 127-35.

81. Youell P.D, Wise R.G, Bentley D.E, Dickinson M.R, King T.A, Tracey I, et al. Lateralisation of nociceptive processing in the human brain: a functional magnetic resonance imaging study. Neuroimage 2004; 23(3):1068-077.

82. Chapman C.E, Bushnell M.C, Miron D, Duncan GH, Lund JP. Sensory perception during movement in man. Exp Brain Res 1987; 68(3): 516-24.

83. Eccleston C. The attentional control of pain: methodological and theoretical concerns. Pain 1995;63(1): 3-10.

84. Miron D, Duncan G.H, Bushnell M.C. Effects of attention on the intensity and unpleasantness of thermal

pain. Pain 1989; 39(3): 345-52.

85. Peyron R, Garcia-Larrea L, Gregoire M.C, Costes N, Convers P, Lavenne F, et al. Haemodynamic brain responses to acute pain in humans: sensory and attentional networks. Brain 1999; 122 (Pt 9): 1765-780.

86. Brooks J.C, Nurmikko T.J, Bimson W.E, Singh K.D, Roberts N. fMRI of thermal pain: effects of stimulus laterality and attention. Neuroimage 2002; 15(2): 293-301.

87. Casey K.L, Morrow T.J, Lorenz J, Minoshima S. Temporal and spatial dynamics of human forebrain activity during heat pain: analysis by positron emission tomography. J Neurophysiol 2001; 85(2): 951-59.

88. Lorenz J, Casey K.L. Imaging of acute versus pathological pain in humans. Eur J Pain 2005; 9(2): 163-65.

89. Iadarola M.J, Max M.B, Berman K.F, Byas-Smith M.G, Coghill R.C, Gracely R.H, et al. Unilateral decrease in thalamic activity observed with positron emission tomography in patients with chronic neuropathic pain. Pain 1995; 63(1): 55-64.

90. Bullitt E. Induction of c-fos-like protein within the lumbar spinal cord and thalamus of the rat following peripheral stimulation. Brain Res 1989; 493(2): 391-97.

91. Ceccarelli I, Scaramuzzino A, Massafra C, Aloisi A.M. The behavioral and neuronal effects induced by repetitive nociceptive stimulation are affected by gonadal hormones in male rats. Pain 2003; 104(1-2):35-47.

92. Narita M, Ozaki S, Ise Y, Yajima Y, Suzuki T. Change in the expression of c-fos in the rat brain following sciatic nerve ligation. Neurosci Lett 2003; 352(3): 231-33.

93. Bruggemann J, Galhardo V, Apkarian A.V. Immediate reorganization of the rat somatosensory thalamus after partial ligation of sciatic nerve. J Pain 2001;2(4):220-28.

94. Goettl V.M, Huang Y, Hackshaw K.V, Stephens R.L, Jr. Reduced basal release of serotonin from the ventrobasal thalamus of the rat in a model of neuropathic pain. Pain 2002; 99(1-2): 359-66.

95. Salt T.E, Eaton S.A. Function of non-NMDA receptors and NMDA receptors in synaptic responses to natural somatosensory stimulation in the ventrobasal thalamus. Exp Brain Res 1989; 77(3): 646-52.

96. Dougherty P.M, Li Y.J, Lenz F.A, Rowland L, Mittman S. Evidence that excitatory amino acids mediate afferent input to the primate somatosensory thalamus. Brain Res 1996; 728(2): 267-73.

97. Abarca C, Silva E, Sepulveda M.J, Oliva P, Contreras E. Neurochemical changes after morphine, dizocilpine or riluzole in the ventral posterolateral thalamic nuclei of rats with hyperalgesia. Eur J Pharmacol 2000;403(1-2):67-74.

98. Kolhekar R, Murphy S, Gebhart G.F. Thalamic NMDA receptors modulate inflammation-produced hyperalgesia in the rat. Pain 1997; 71(1): 31-40.

99. Bordi F, Quartaroli M. Modulation of nociceptive transmission by NMDA/glycine site receptor in the ventroposterolateral nucleus of the thalamus. Pain 2000; 84(2-3): 213-24.

100. Eaton S.A, Salt T.E. Thalamic NMDA receptors and nociceptive sensory synaptic transmission. Neurosci Lett 1990; 110(3): 297-302.

101. Buller A.L, Larson H.C, Schneider B.E, Beaton J.A, Morrisett R.A, Monaghan D.T. The molecular basis of NMDA receptor subtypes: native receptor diversity is predicted by subunit composition. J Neurosci 1994;14(9): 5471-484.

102. Xie Y.F, Tang J.S, Jia H. The roles of different types of glutamate receptors involved in the mediation of

nucleus submedius (Sm) glutamate-evoked antinociception in the rat. Brain Res 2003; 988(1-2):146-53.

Repository Staff Only: item control page
 
 
 
 
 
   
© Copyright 2007 MyAIS Faculty of Computer Science and Information Technology, University of Malaya – All Rights Reserved. Malaysian Abstracting and Indexing System is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.