Author, Subjects, Keywords

Cited Author

 
 
   » By Author or Editor
 » Browse Author by Alphabet
 » By Journal
 » By Subjects
 » By Affiliations
 » By Type
 » By Year
 » By Latest Additions
 
 
   » By Author
 » Top 20 Authors
 » Top 20 Article
 » Top 20 Journal Cited
 » Top 20 Cited
 » Top 20 Author Cited
 » Usage Since Sept 2007


 
 
 

Login | Create Account

Survival in Patients with Non-Small Cell Lung Cancer Who Opted Out of Cancer-Specific Therapy.

Loh, Li Cher and Tan, Ru Yu and Chan, Li Yen and Govindaraju, Selvaratnam and Ratnavelu, Kananathan and Kumar, Shalini and Raman, Sree and Vijayasingham, Pillai and Thayaparan, Tamizi (2006) Survival in Patients with Non-Small Cell Lung Cancer Who Opted Out of Cancer-Specific Therapy. Malaysian Journal of Medical Sciences, 13 (1). pp. 24-29. ISSN 1394195X

Full text not available from this repository.

Official URL: http://www.medic.usm.my/publication/mjms/

Affiliations

International Medical University, IMU Lung Research
International Medical University, IMU Lung Research
International Medical University, IMU Lung Research
Nilai Cancer Institute
Nilai Cancer Institute
Seremban Hospital, Dept. of Pathology
Seremban Hospital, Dept. of Medicine
Seremban Hospital, Dept. of Medicine
Seremban Hospital, Dept. of Medicine

Abstract

In Malaysia, many patients opted out of cancer-specific treatment for various reasons. This study was undertaken to investigate the survival rate of patients with stages I to III non-small cell lung cancer (NSCLC) who opted out of treatment, compared with those who accepted treatment. Case records of 119 patients diagnosed with NSCLC between 1996 and 2003 in two urban-based hospitals were retrospectively examined. Survival status was ascertained from follow-up medical clinic records or telephone contact with patients or their next-of-kin. Median (25-75% IQR) survival rate for 79 patients who accepted and 22 patients who opted out of treatment, were 8.6 (16.0-3.7) and 2.2 (3.5-0.8) months respectively [log rank p< 0.001, Kaplan-Meier survival analysis]. Except for proportionately more patients with large cell carcinoma who declined treatment, there was no significant difference between the two groups in relation with age, gender, ethnicity, tumour stage, and time delays between symptom onset and treatment or decision-to-treat. We concluded that there was a small but significant survival benefit in accepting cancer-specific treatment. The findings imply that there is no effective alternative therapy to cancer-specific treatment in improving survival. However, overall prognosis for patients with NSCLC remains dismal.

Item Type:Journal
Keywords:Non-small cell lung cancer, survival, cancer-specific treatment, Malaysia
Subjects:R Medicine
ID Code:842

1. Janssen-Heijnen M.L., Gatta G., Forman D., Capocaccia R., Coebergh J.W. Variation in survival of patients with lung cancer in Europe, 1985-1989. Eur J Cancer 1998; 34 : 2191-196.

2. Northern and Yorkshire Cancer Registry and Information Service (NYCRIS). A report on incidence and management for the main sites of cancer 1999; Leeds, NYCRIS 2002: 1-56.

3. Lim G.C.C., Yahaya H., Lim T.O. The first report of the national cancer registry cancer incidence in Malaysia 2002. National Cancer Registry, Ministry of Health Malaysia 2002.

4. Efimov G.A., Krasnov Yu O., Chigirinskii L.M. [Survival of lung cancer patients who refused surgical treatment]. Vopr Onkol 1980; 26: 79-84.

5. Chapple A., Ziebland S., McPherson A. Stigma, shame, and blame experienced by patients with lung cancer: qualitative study. BMJ 2004; 328:1470.

6. Ginsburg M.L., Quirt C., Ginsburg A.D., MacKillop W.J. Psychiatric illness and psychosocial concerns of patients with newly diagnosed lung cancer. CMAJ 1995; 152: 701-8.

7. Clipp E.C., George L.K. Patients with cancer and their spouse caregivers. Perceptions of the illness experience. Cancer 1992; 69: 1074-9.

8. Heggenhougen H.K. Bomohs, doctors and sinsehs—medical pluralism in Malaysia. Soc Sci Med (Med Anthropol) 1980; 14B: 235-44.

9. Chen P.C. Traditional and modern medicine in Malaysia. Am J Chin Med 1979; 7: 259-75.

10. Ooi G.L. Chinese medicine in Malaysia and Singapore: the business of healing. Am J Chin Med 1993; 21: 197-212.

11. Eng L.S. Cases discharged “A.O.R.” A study of 110 cases in Kulim district hospital. Med J Malaya 1968;23: 289-94.

12. Roy R.N. Problems of tuberculosis management in Sabah. N Z Med J 1972; 76: 97-101.

13. Li Y.M, Ohno Y., Minatoguchi S., et al. Extracts from the roots of Lindera strychifolia induces apoptosis in lung cancer cells and prolongs survival of tumorbearing mice. Am J Chin Med 2003; 31: 857-69.

14. Hsu Y.L., Kuo P.L., Lin C.C. The proliferative nhibition and apoptotic mechanism of Saikosaponin D in human non-small cell lung cancer A549 cells. Life Sci 2004;

75: 1231-42.

15. Li J.H. A study on treatment of lung cancer by combined therapy of traditional Chinese medicine and chemotherapy. Zhongguo Zhong Xi Yi Jie He Za Zhi 1996; 16: 136-8.

16. Gopal P., Iyawoo K., Hooi Lai Ngoh, Parameswary V. Lung cancer: a review of 589 Malaysian patients. Med J Malaysia 1988; 43: 288-96.

17. Menon M.A., Saw H.S. Lung cancer in Malaysia. Thorax 1979; 34: 269-73.

18. Liam C.K., Lim K.H., Wong C.M. Lung cancer in patients younger than 40 years in a multiracial Asian country. Respirology 2000; 5: 355-61.

19. Hooi L.N. What are the clinical factors that affect quality of life in adult asthmatics? Med J Malaysia 2003; 58: 506-15.

20. Marin I., Higgins R. (Relationship with the patient with bronchopulmonary cancer. Psychological, family and

social aspects). Rev Mal Respir 1984; 1: 277-84.

21. Moore C. Making a difference in oncology nursing. Fla Nurse 1999; 47: 15.

Repository Staff Only: item control page
 
 
 
 
 
   
© Copyright 2007 MyAIS Faculty of Computer Science and Information Technology, University of Malaya – All Rights Reserved. Malaysian Abstracting and Indexing System is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.