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Evaluation of the Teratogenicity of Aqueous Extract of Labisia pumila var. alata in Rats

Wan Ezumi Mohd. Fuad, and Siti Amrah Sulaiman, and Mohamad Nasrul Islam, and Mohd. Suhaimi Abdul Wahab, and Syed Mohsin Sahil Jamallulail, (2005) Evaluation of the Teratogenicity of Aqueous Extract of Labisia pumila var. alata in Rats. Malaysian Journal of Medical Sciences, 12 (2). pp. 13-21. ISSN 1394195X

Full text not available from this repository.

Official URL: http://www.medic.usm.my/publication/mjms/

Affiliations

Universiti Sains Malaysia, School of Medical Sciences, Dept. of Pharmacology
Universiti Sains Malaysia, School of Medical Sciences, Dept. of Anatomy

Abstract

A dose range study to assess the teratogenic potential of aqueous extract of Labisia pumila var. alata (Kacip Fatimah) was conducted in rodents. The extract at doses of 0 (control), 2, 20, 200, 400, 1000 mg/kg/day were respectively administered by gavaging to 6 groups of pregnant Sprague Dawley rats from day 6 through day 16 of pregnancy and sacrificed on day 21. No significant agent-related effects including changes in maternal body weight (MBW) nor weight gain were observed. The corrected maternal body weights (CMBW) were slightly higher in animals receiving low dose extracts (2 mg/kg/day) as compared to all groups of animals. However, body weight differences were not statistically significant. Gravid uterine weight, number of corpora lutea, number of implantation sites, percentage of foetal resorptions, number of life foetuses, foetal weight and foetal sex ratio showed no significant differences among all group animals. None of the foetuses from all dams showed evidence of external congenital malformations. These findings may suggest that aqueous extracts of Labisia pumila var. alata up to 1000 mg/kg/day statistically do not show any significant teratogenic effects in rats but do affect the maternal body weight and this is dose dependent.

Item Type:Journal
Additional Information:The authors acknowledge IRPA Top Down Grant (no: 304 PPSP 6112213) of Malaysia for its financial support.
Keywords:Labisia pumila var. alata, aqueous extract, teratogenicit, Kacip fatmah; Pharmacology
Subjects:R Medicine, Dentistry, Pharmacy, Nursing
ID Code:863

1. Burkill I.H. A dictionary of the economic products of the Malay Peninsula. London: Crown Agent, 1935.

2. Stone B.C. Notes on the Genus Labisia Lindl. (Myrsinaceae). Malayan Nature Journal 1988; 42: 43-51.

3. Zakaria M, Mohd M.A. Traditional Malay medicinal plants. Kuala Lumpur: Penerbit Fajar Bakti Sdn. Bhd,1994.

4. Houghton P.J., Jamal J.A., Milligan S. Studies on Labisia pumila herb and its commercial products. Journal Pharm. Pharmacol. 1999; 51 (Supplement): 236.

5. Nazaimoon W.M.W. Estrogenic and androgenic activities of Kacip Fatimah (Labisia pumila var. alata and var. pumila). Project summary. 2002.

6. Ismail N., Manaf M.A., Ismail Z. Pharmacognosical characterisation of Labisia Pothoina. Trends in Traditional Medicine Research Proceedings of the International Conference on the Use of Traditional Medicine & Other Natural Products in Health Care 1993, Penang, Malaysia: 574.

7. Smithells R.W. The demonstration of teratogenic effects of drugs in humans. In: Hawkins DF, ed. Drugs and pregnancy: Human teratogenesis and related problems. 2 ed. Edinburgh: Churchill Livingstone, 1987.

8. Neubert D., Jodicke B., Welsch F. Reproduction and Development. In: Marquardt H, Schafer SG, McClellan R., Welsch F, eds. Toxicology. San Diego: Academic Press, 1999: 493-4.

9. Manson J.M., Kang Y.J. Test methods for assessing female reproductive and developmental toxicology. In: Hayes AW, ed. Principles and methods of toxicology. 3 ed. New York: Raven Press Ltd, 1994: 1026-33.

10. Detection of Toxicity to Reproduction for Medicinal Products. In: ICH Harmonised Tripartite Guideline; 24 June 1993: Endorsed by the ICH Steering Committee at Step 4 of the ICH Process; 24 June 1993.p. 5.

11. Nuradilah M., Sani M.N.H., Anom H.S., Balaspramaniam A, Aliah T, Nazaimoon WMW. Effects of Kacip Fatimah water extract on hormonal profile of normal female rats. The 4th International Traditional / Complementary Medicine Conference and Exhibition (INTRACOM 2002) 2002, Sunway Pyramid Convention Centre.

12. Paumgartten F.R.J., De-Carvalho R.R., Souza C.A.M., Madi K., Chahoud I. Study of the effects of B-myrcene on rat fertility and general reproductive performance. Brazillian Journal of Medical and Biological Research 1997; 31: 955-965.

13. World Health Organization (WHO). Environmental Health Criteria. Principles for evaluating health risks to reproduction associated with exposure to chemicals, ed: WHO (World Health Organization), 2001: 1-187.

14. Manson J.M., Zenick H., Costlow R.D. Teratology test methods for laboratory animals. In: Hayes AW, ed. Principles of toxicology. New York, Raven Press, 1982:141-181.

15. Organization for Economic Co-operation and Development (OECD). Guideline for the testing of chemicals. Proposal for updating guideline 414. Prenatal development toxicity study: Organization for Economic Co-operation and Development (OECD), 2001: 1-13.

16. Sharp P.E., Regina M.C.L. Important biological features. In: Suckow MA, ed. The laboratory rat. A volume in the laboratory animal pocket reference series. Boca Raton: CRC Press LLC, 1998: 7.

17. Green S.B., Salkind N.J., Akey T.M. Using SPSS for windows: Analyzing and understanding data. 2 ed: Prentice-Hall, 2000.

18. U.S Environmental Protectian Agency. Guidelines for Reproductive Toxicity Risk Assesment. In: Office of Research and Development, ed: U.S Environmental Protectian Agency, 1996: 1-163.

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