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The Co-existence of Pure Red Cell Aplasia and Autoimmune Haemolytic Anaemia in a Child with Malignant Lymphoma.

Suhair Abbas Ahmed, and Rosline Hassan, (2005) The Co-existence of Pure Red Cell Aplasia and Autoimmune Haemolytic Anaemia in a Child with Malignant Lymphoma. Malaysian Journal of Medical Sciences, 12 (2). pp. 56-59. ISSN 1394195X

Full text not available from this repository.

Official URL: http://www.medic.usm.my/publication/mjms/

Affiliations

Universiti Sains Malaysia, School of Medical Sciences, Dept. of Haematology

Abstract

The association between pure red cell aplasia (PRCA) and autoimmune haemolytic anaemia (AIHA) has rarely been reported. PRCA represents an isolated process, characterized by normochromic, normocytic anaemia, eticulocytopenia and erythroid hypoplasia in the bone marrow, and may be attributable to infection with Parvo virus B19. AIHA is a condition in which peripheral red blood cell destruction is induced by the presence of autoantibodies. However, the co-existence of these conditions is very rare, since only few cases of PRCA and AIHA associated with malignant lymphoma (ML)were reported. A case of PRCA and AIHA was detected and described, for the first time in Malaysia, in a 10-year-old child suffering from non-Hodgkin lymphoma from the Department of Haematology, Universiti Sains Malaysia. Following the induction course of chemotherapy, the patient turned anaemic, with tendency for red cell clumping, reticulocytopenia and anisocytosis. AIHA was suspected in spite of the weak Coomb reaction obtained. The bone marrow aspirate revealed the presence of giant pronormoblasts, suggesting PRCA. Serological tests for Parvo virus and other viruses were negative.

Item Type:Journal
Keywords:Pure red cell aplasia, autoimmune haemolytic anaemia, malignant lymphoma.
Subjects:R Medicine
ID Code:868

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