Effects of Palm Vitamin E Against Oxidative Damage in Streptozotocin-induced Diabetic Rats Siti Balkis Budinauthor Nor Fadilah Rajabauthor Khairol Osmanauthor Abdul Gapor Mat Top author Wan Nazaimoon Wan Mohamudauthor Mokhtar Abu Bakarauthor Jamaludin MohamedauthorPalm vitamin E, which rich in tocotrienol is a highly effective antioxidant and able to reduce oxidative stress in various pathological conditions. Diabetes mellitus is often associated with increase in the production of reactive oxygen species together with reduction in antioxidants levels. In order to elucidate the antioxidative effects of palm vitamin E, we investigated the effects of 8 weeks supplementation with palm vitamin E on glycaemic status, malondialdehyde levels and DNA damage in Streptozotocininduced diabetic rats. Alkaline Comet Assay assessed protective effects against DNA damage to peripheral blood. Streptozotocin diabetic rats were force fed daily with palm vitamin E (200mg/kg body weight), from day three of diabetes condition established. Following eight weeks of supplementation, palm vitamin E significantly improved fasting blood glucose and glycosylated hemoglobin. The increased in plasma malondialdehyde levels were also inhibited and the levels of oxidative DNA damage of peripheral lymphocyte was reduced. This suggested that palm vitamin E has the potential in improving glycaemic status and also the protective effects against oxidative damage by inhibiting the increased in malondialdehyde and preventing DNA damage in Streptozotocin-induced diabetic rats.Q Science, Computer ScienceR Medicine, Dentistry, Pharmacy, Nursing2006Malaysian Society for Biochemistry and Molecular BiologyJournal