<mets:mets LABEL="Eprints Item" xsi:schemaLocation="http://www.loc.gov/METS/ http://www.loc.gov/standards/mets/mets.xsd http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-0.xsd" xmlns:xlink="http://www.w3.org/1999/xlink" OBJID="oai:myais.fsktm.um.edu.my:2255" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:mods="http://www.loc.gov/mods/v3" xmlns:mets="http://www.loc.gov/METS/"><mets:metsHdr CREATEDATA="2008-12-02T19:12:43Z"><mets:agent TYPE="ORGANIZATION" ROLE="CUSTODIAN"><mets:name>Malaysian Abstracting and Indexing System</mets:name></mets:agent></mets:metsHdr><mets:dmdSec ID="DMD_oai:myais.fsktm.um.edu.my:2255_mods"><mets:mdWrap MDTYPE="mods"><mets:xmlData><mods:titleInfo><mods:title>Hepatitis B Virus Genotypes and Pre-core / Core Promoter Mutations in Malaysian Carriers</mods:title></mods:titleInfo><mods:name type="personal"><mods:namePart type="given"> </mods:namePart><mods:namePart type="family">Ton, So Har</mods:namePart><mods:role><mods:roleTerm type="text">author</mods:roleTerm></mods:role></mods:name><mods:name type="personal"><mods:namePart type="given"> </mods:namePart><mods:namePart type="family">Tan, Sui Meng</mods:namePart><mods:role><mods:roleTerm type="text">author</mods:roleTerm></mods:role></mods:name><mods:name type="personal"><mods:namePart type="given"> </mods:namePart><mods:namePart type="family">Koo, Boo Siang</mods:namePart><mods:role><mods:roleTerm type="text">author</mods:roleTerm></mods:role></mods:name><mods:name type="personal"><mods:namePart type="given"> </mods:namePart><mods:namePart type="family">Mazlam Zawawi</mods:namePart><mods:role><mods:roleTerm type="text">author</mods:roleTerm></mods:role></mods:name><mods:name type="personal"><mods:namePart type="given"> </mods:namePart><mods:namePart type="family">Nagalingam Thanaletchimy</mods:namePart><mods:role><mods:roleTerm type="text">author</mods:roleTerm></mods:role></mods:name><mods:abstract>HBV-DNA from 120 HBsAg-positive Malaysians was genotyped and mutations at the core promoter and precore regions were studied. The dominant genotype observed was genotype B (53.4%), followed by genotype C (13.6%) and 1 each of genotypes D and E (1.1% ). A high proportion of the carriers (30.7%) showed a co-infection of genotypes B and C. When the carriers were grouped into asymptomatic (ASM) and symptomatic (SYM) individuals, it was found that SYM individuals showed a significantly higher proportion of co-infection compared to ASM individuals (46.2% vs. 8.3%, P &lt; 0.05). Correlation analysis with the mutations showed a significant correlation between genotype C and T1762A1764 variant (P &lt; 0.05). A second observation showed positive correlation between C1858 variants and individuals with co-infection of genotypes B and C while T1858 variants were strongly linked to genotype B-infected individuals (P &lt; 0.05). In conclusion it was found that the predominant genotype in our study was B followed by C and that genotype B was significantly linked to T1858 variants while T1762 A1764 variants had significant correlation with genotype C.</mods:abstract><mods:classification authority="lcc">Q Science, Computer Science</mods:classification><mods:classification authority="lcc">R Medicine, Dentistry, Pharmacy, Nursing</mods:classification><mods:originInfo><mods:dateIssued encoding="iso8061">2005</mods:dateIssued></mods:originInfo><mods:originInfo><mods:publisher>Malaysian Society for Biochemistry and Molecular Biology</mods:publisher></mods:originInfo><mods:genre>Journal</mods:genre></mets:xmlData></mets:mdWrap></mets:dmdSec><mets:amdSec ID="TMD_oai:myais.fsktm.um.edu.my:2255"><mets:rightsMD ID="rights_oai:myais.fsktm.um.edu.my:2255_mods"><mets:mdWrap MDTYPE="mods"><mets:xmlData><mods:useAndReproduction>
<p><strong>For work being deposited by its own author:</strong> 
In self-archiving this collection of files and associated bibliographic 
metadata, I grant Malaysian Abstracting and Indexing System the right to store 
them and to make them permanently available publicly for free on-line. 
I declare that this material is my own intellectual property and I 
understand that Malaysian Abstracting and Indexing System does not assume any 
responsibility if there is any breach of copyright in distributing these 
files or metadata. (All authors are urged to prominently assert their 
copyright on the title page of their work.)</p>

<p><strong>For work being deposited by someone other than its 
author:</strong> I hereby declare that the collection of files and 
associated bibliographic metadata that I am archiving at 
Malaysian Abstracting and Indexing System) is in the public domain. If this is 
not the case, I accept full responsibility for any breach of copyright 
that distributing these files or metadata may entail.</p>

<p>Clicking on the deposit button indicates your agreement to these 
terms.</p>
    </mods:useAndReproduction></mets:xmlData></mets:mdWrap></mets:rightsMD></mets:amdSec><mets:fileSec></mets:fileSec><mets:structMap><mets:div AMDID="TMD_oai:myais.fsktm.um.edu.my:2255" DMDID="DMD_oai:myais.fsktm.um.edu.my:2255_mods"></mets:div></mets:structMap></mets:mets>