2255 13 archive 2 disk0/00/00/22/55 2008-07-01 15:24:57 2008-07-01 15:24:57 2008-07-01 15:24:57 article show Ton, So Har Tan, Sui Meng Koo, Boo Siang Mazlam Zawawi Nagalingam Thanaletchimy Monash University Malaysia. School of Arts and Sciences Monash University Malaysia. School of Arts and Sciences Monash University Malaysia. School of Arts and Sciences pub Q R none hepatitis B virus, genotype, precore and core promoter mutations HBV-DNA from 120 HBsAg-positive Malaysians was genotyped and mutations at the core promoter and precore regions were studied. The dominant genotype observed was genotype B (53.4%), followed by genotype C (13.6%) and 1 each of genotypes D and E (1.1% ). A high proportion of the carriers (30.7%) showed a co-infection of genotypes B and C. When the carriers were grouped into asymptomatic (ASM) and symptomatic (SYM) individuals, it was found that SYM individuals showed a significantly higher proportion of co-infection compared to ASM individuals (46.2% vs. 8.3%, P < 0.05). Correlation analysis with the mutations showed a significant correlation between genotype C and T1762A1764 variant (P < 0.05). A second observation showed positive correlation between C1858 variants and individuals with co-infection of genotypes B and C while T1858 variants were strongly linked to genotype B-infected individuals (P < 0.05). 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