@article{myais2266,
          volume = {11},
          number = {1},
           month = {["lib/utils:month\verb1_12266" not defined]},
          author = {  Shahrul Hisham Zainal Ariffin and   Rohaya Megat Abdul Wahab and   Zaidah Zainal Ariffin and   Roslina Samsudin and   Siti Fatimah Mohd Noor and   Whetton, A.D.},
           title = {Functions of Human GM-CSF $\alpha$-Subunit in Mediating Self-Renewal or Differentiation on FDCP-Mix Cells},
       publisher = {Malaysian Society for Biochemistry and Molecular Biology},
            year = {2005},
         journal = {Malaysian Journal of Biochemistry and Molecular Biology},
           pages = {6--12},
        keywords = {GM-CSF receptor, multipotent cells, differentiation},
             url = {http://myais.fsktm.um.edu.my/2266/},
        abstract = {Activation of human GM-CSF receptor ectopically expressed in polyclonal murine FDCP-Mix multipotent cells, stimulate selfrenewal or myeloid differentiation. Bioinformatic analysis revealed a potentially important tripeptide region in the ?-subunits cytosolic domain. Mutation of hGM-CSF receptor ?-subunit (hGM-CSFR?) involving the respective tripeptides altered the receptor function compared to the wild type receptor. The mutated hGM-CSFR? clonal cells signaled for self-renewal whilst the wild type receptor produce cell differentiations in the presence of hGM-CSF cytokines. These results showed that cytosolic region of the ?-subunit was critically important for developmental decision in multipotent cell, indicating that signaling specificity for cell fate resides in the receptor?s structure.}
}