title: Functions of Human GM-CSF α-Subunit in Mediating Self-Renewal or Differentiation on FDCP-Mix Cells
creator: Shahrul Hisham Zainal Ariffin,  
creator: Rohaya Megat Abdul Wahab,  
creator: Zaidah Zainal Ariffin,  
creator: Roslina Samsudin,  
creator: Siti Fatimah Mohd Noor,  
creator: Whetton, A.D.,  
subject: Q Science, Computer Science
subject: R Medicine, Dentistry, Pharmacy, Nursing
description: Activation of human GM-CSF receptor ectopically expressed in polyclonal murine FDCP-Mix multipotent cells, stimulate selfrenewal or myeloid differentiation. Bioinformatic analysis revealed a potentially important tripeptide region in the α-subunits cytosolic domain. Mutation of hGM-CSF receptor α-subunit (hGM-CSFRα) involving the respective tripeptides altered the receptor function compared to the wild type receptor. The mutated hGM-CSFRα clonal cells signaled for self-renewal whilst the wild type receptor produce cell differentiations in the presence of hGM-CSF cytokines. These results showed that cytosolic region of the α-subunit was critically important for developmental decision in multipotent cell, indicating that signaling specificity for cell fate resides in the receptor’s structure.
publisher: Malaysian Society for Biochemistry and Molecular Biology
date: 2005
type: Journal
type: PeerReviewed
relation: http://ejum.fsktm.um.edu.my/ArticleInformation.aspx?ArticleID=616
identifier: Shahrul Hisham Zainal Ariffin, and Rohaya Megat Abdul Wahab, and Zaidah Zainal Ariffin, and Roslina Samsudin, and Siti Fatimah Mohd Noor, and Whetton, A.D., (2005) Functions of Human GM-CSF α-Subunit in Mediating Self-Renewal or Differentiation on FDCP-Mix Cells. Malaysian Journal of Biochemistry and Molecular Biology, 11 (1). pp. 6-12. ISSN ISSN 1511-2616
relation: http://myais.fsktm.um.edu.my/2266/