TY  - JOUR
ID  - myais2266
UR  - http://ejum.fsktm.um.edu.my/ArticleInformation.aspx?ArticleID=616
IS  - 1
A1  - Shahrul Hisham Zainal Ariffin,  
A1  - Rohaya Megat Abdul Wahab,  
A1  - Zaidah Zainal Ariffin,  
A1  - Roslina Samsudin,  
A1  - Siti Fatimah Mohd Noor,  
A1  - Whetton, A.D.,  
Y1  - 2005///
N2  - Activation of human GM-CSF receptor ectopically expressed in polyclonal murine FDCP-Mix multipotent cells, stimulate selfrenewal or myeloid differentiation. Bioinformatic analysis revealed a potentially important tripeptide region in the ?-subunits cytosolic domain. Mutation of hGM-CSF receptor ?-subunit (hGM-CSFR?) involving the respective tripeptides altered the receptor function compared to the wild type receptor. The mutated hGM-CSFR? clonal cells signaled for self-renewal whilst the wild type receptor produce cell differentiations in the presence of hGM-CSF cytokines. These results showed that cytosolic region of the ?-subunit was critically important for developmental decision in multipotent cell, indicating that signaling specificity for cell fate resides in the receptor?s structure.
PB  - Malaysian Society for Biochemistry and Molecular Biology
JF  - Malaysian Journal of Biochemistry and Molecular Biology
VL  - 11
KW  - GM-CSF receptor
KW  -  multipotent cells
KW  -  differentiation
SN  - ISSN 1511-2616
TI  - Functions of Human GM-CSF ?-Subunit in Mediating Self-Renewal or Differentiation on FDCP-Mix Cells
SP  - 6
AV  - none
EP  - 12
ER  -